abnormal tumor necrosis factor secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008556)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008556
Similar Terms
Downloads & Tools

Genes

172 gene mutations causing the abnormal tumor necrosis factor secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRB2 adrenoceptor beta 2, surface
AIM2 absent in melanoma 2
AIRE autoimmune regulator
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APOE apolipoprotein E
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
AZI2 5-azacytidine induced 2
B2M beta-2-microglobulin
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BIRC3 baculoviral IAP repeat containing 3
BPIFA1 BPI fold containing family A, member 1
CARD9 caspase recruitment domain family, member 9
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCAR2 cell cycle and apoptosis regulator 2
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD200R1 CD200 receptor 1
CD274 CD274 molecule
CD300A CD300a molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD69 CD69 molecule
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC6A C-type lectin domain family 6, member A
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCL6 chemokine (C-X-C motif) ligand 6
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DMD dystrophin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
FADS1 fatty acid desaturase 1
FASTK Fas-activated serine/threonine kinase
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
FFAR2 free fatty acid receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FYN FYN proto-oncogene, Src family tyrosine kinase
GFI1 growth factor independent 1 transcription repressor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR34 G protein-coupled receptor 34
GPR65 G protein-coupled receptor 65
GRN granulin
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSF1 heat shock transcription factor 1
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IER3 immediate early response 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNGR1 interferon gamma receptor 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
LBP lipopolysaccharide binding protein
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LPAR2 lysophosphatidic acid receptor 2
LTA lymphotoxin alpha
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MAVS mitochondrial antiviral signaling protein
MERTK MER proto-oncogene, tyrosine kinase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR155 microRNA 155
MMP28 matrix metallopeptidase 28
MMP7 matrix metallopeptidase 7
MUC2 mucin 2, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
MYO1G myosin IG
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NLRC3 NLR family, CARD domain containing 3
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PIGR polymeric immunoglobulin receptor
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G2D phospholipase A2, group IID
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POMC proopiomelanocortin
PRF1 perforin 1 (pore forming protein)
PRKCE protein kinase C, epsilon
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYCARD PYD and CARD domain containing
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RC3H2 ring finger and CCCH-type domains 2
RETNLB resistin like beta
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIPK2 receptor-interacting serine-threonine kinase 2
SASH3 SAM and SH3 domain containing 3
SELK selenoprotein K
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SOCS2 suppressor of cytokine signaling 2
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
SSTR4 somatostatin receptor 4
STIM1 stromal interaction molecule 1
STK17B serine/threonine kinase 17b
STX11 syntaxin 11
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TIMP3 TIMP metallopeptidase inhibitor 3
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNIP1 TNFAIP3 interacting protein 1
TOLLIP toll interacting protein
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAFD1 TRAF-type zinc finger domain containing 1
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIM27 tripartite motif containing 27
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
ZC3H12A zinc finger CCCH-type containing 12A