abnormal tumor necrosis factor level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008752)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008752
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Genes

126 gene mutations causing the abnormal tumor necrosis factor level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADORA2B adenosine A2b receptor
AHR aryl hydrocarbon receptor
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARID5A AT rich interactive domain 5A (MRF1-like)
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
BBS12 Bardet-Biedl syndrome 12
BRD2 bromodomain containing 2
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CBS cystathionine-beta-synthase
CCL13 chemokine (C-C motif) ligand 13
CD14 CD14 molecule
CD19 CD19 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLIC4 chloride intracellular channel 4
CPB2 carboxypeptidase B2 (plasma)
CREBBP CREB binding protein
CUX1 cut-like homeobox 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FASLG Fas ligand (TNF superfamily, member 6)
FFAR2 free fatty acid receptor 2
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXO1 forkhead box O1
FOXP3 forkhead box P3
HCK HCK proto-oncogene, Src family tyrosine kinase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTRA2 HtrA serine peptidase 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL18 interleukin 18
IL22 interleukin 22
IL27RA interleukin 27 receptor, alpha
IL6R interleukin 6 receptor
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LEP leptin
LGMN legumain
LIF leukemia inhibitory factor
LTA lymphotoxin alpha
MAGED1 melanoma antigen family D1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAVS mitochondrial antiviral signaling protein
MEFV Mediterranean fever
MEP1A meprin A, alpha (PABA peptide hydrolase)
MERTK MER proto-oncogene, tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MSTN myostatin
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NGFR nerve growth factor receptor
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NPY1R neuropeptide Y receptor Y1
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
PARP1 poly (ADP-ribose) polymerase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4D phosphodiesterase 4D, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PGLYRP2 peptidoglycan recognition protein 2
PILRB paired immunoglobin-like type 2 receptor beta
PRF1 perforin 1 (pore forming protein)
PRKCE protein kinase C, epsilon
RAB27A RAB27A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RC3H1 ring finger and CCCH-type domains 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RUNX3 runt-related transcription factor 3
S100A9 S100 calcium binding protein A9
SARM1 sterile alpha and TIR motif containing 1
SH3BP2 SH3-domain binding protein 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT3 sirtuin 3
SLAMF6 SLAM family member 6
SORT1 sortilin 1
SPON2 spondin 2, extracellular matrix protein
SRA1 steroid receptor RNA activator 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX11 syntaxin 11
TBC1D23 TBC1 domain family, member 23
TBK1 TANK-binding kinase 1
TBX21 T-box 21
THBD thrombomodulin
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TREM2 triggering receptor expressed on myeloid cells 2
TRIM21 tripartite motif containing 21
TWIST2 twist family bHLH transcription factor 2
UNC93B1 unc-93 homolog B1 (C. elegans)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZC3H12A zinc finger CCCH-type containing 12A