abnormal thymus size Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description deviation from the normal size of the thymus (Mammalian Phenotype Ontology, MP_0002364)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002364
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Genes

250 gene mutations causing the abnormal thymus size phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADRM1 adhesion regulating molecule 1
AFF1 AF4/FMR2 family, member 1
AIRE autoimmune regulator
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP1 Rho GTPase activating protein 1
ARHGAP5 Rho GTPase activating protein 5
ARID5B AT rich interactive domain 5B (MRF1-like)
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAG4 BCL2-associated athanogene 4
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BOK BCL2-related ovarian killer
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACYBP calcyclin binding protein
CARM1 coactivator-associated arginine methyltransferase 1
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCNB2 cyclin B2
CCND3 cyclin D3
CD247 CD247 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHD7 chromodomain helicase DNA binding protein 7
CISH cytokine inducible SH2-containing protein
COL10A1 collagen, type X, alpha 1
CRIP3 cysteine-rich protein 3
CTC1 CTS telomere maintenance complex component 1
CTSD cathepsin D
CTSV cathepsin V
CUX1 cut-like homeobox 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYS1 cystin 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAD1 defender against cell death 1
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DFNB31 deafness, autosomal recessive 31
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNASE2 deoxyribonuclease II, lysosomal
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
EDNRA endothelin receptor type A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELAVL1 ELAV like RNA binding protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FES FES proto-oncogene, tyrosine kinase
FGF10 fibroblast growth factor 10
FGF23 fibroblast growth factor 23
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FUS FUS RNA binding protein
FZD9 frizzled class receptor 9
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GFI1 growth factor independent 1 transcription repressor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GLRA1 glycine receptor, alpha 1
GNAS GNAS complex locus
HAX1 HCLS1 associated protein X-1
HELLS helicase, lymphoid-specific
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA1 homeobox A1
HOXB9 homeobox B9
HR hair growth associated
HTRA2 HtrA serine peptidase 2
HYDIN HYDIN, axonemal central pair apparatus protein
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0101 KIAA0101
KIFAP3 kinesin-associated protein 3
KISS1R KISS1 receptor
KITLG KIT ligand
KL klotho
KLF13 Kruppel-like factor 13
KMT2E lysine (K)-specific methyltransferase 2E
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LMNA lamin A/C
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LRP2 low density lipoprotein receptor-related protein 2
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
NBN nibrin
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCOR1 nuclear receptor corepressor 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NLK nemo-like kinase
NOTCH3 notch 3
PARL presenilin associated, rhomboid-like
PCSK5 proprotein convertase subtilisin/kexin type 5
PFDN1 prefoldin subunit 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIKFYVE phosphoinositide kinase, FYVE finger containing
PIP prolactin-induced protein
PKNOX1 PBX/knotted 1 homeobox 1
PLXND1 plexin D1
PNP purine nucleoside phosphorylase
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTEN phosphatase and tensin homolog
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1 pituitary tumor-transforming 1
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RECQL4 RecQ protein-like 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOH ras homolog family member H
RIPPLY3 ripply transcriptional repressor 3
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RPL27A ribosomal protein L27a
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SAC3D1 SAC3 domain containing 1
SATB1 SATB homeobox 1
SELENBP1 selenium binding protein 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGPL1 sphingosine-1-phosphate lyase 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC46A2 solute carrier family 46, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOAT1 sterol O-acyltransferase 1
SOCS1 suppressor of cytokine signaling 1
SP3 Sp3 transcription factor
SP4 Sp4 transcription factor
SPI1 Spi-1 proto-oncogene
STK36 serine/threonine kinase 36
STK4 serine/threonine kinase 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACC3 transforming, acidic coiled-coil containing protein 3
TBATA thymus, brain and testes associated
TBX1 T-box 1
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TDP2 tyrosyl-DNA phosphodiesterase 2
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAT1 T cell receptor associated transmembrane adaptor 1
TTC7A tetratricopeptide repeat domain 7A
TWIST2 twist family bHLH transcription factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
UNG uracil-DNA glycosylase
VAV1 vav 1 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
WWOX WW domain containing oxidoreductase
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZMPSTE24 zinc metallopeptidase STE24