abnormal thymus physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the primary lymphoid organ that is required for immune system development (Mammalian Phenotype Ontology, MP_0003763)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003763
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Genes

70 gene mutations causing the abnormal thymus physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BIRC6 baculoviral IAP repeat containing 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CD247 CD247 molecule
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
COMMD3-BMI1 COMMD3-BMI1 readthrough
COPS6 COP9 signalosome subunit 6
CORO1A coronin, actin binding protein, 1A
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTX1 deltex 1, E3 ubiquitin ligase
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAIM Fas apoptotic inhibitory molecule
FAS Fas cell surface death receptor
FYN FYN proto-oncogene, Src family tyrosine kinase
HR hair growth associated
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
IL21R interleukin 21 receptor
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
ING1 inhibitor of growth family, member 1
ITPKB inositol-trisphosphate 3-kinase B
KIFAP3 kinesin-associated protein 3
KLF13 Kruppel-like factor 13
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG1 ligase I, DNA, ATP-dependent
MAP2K6 mitogen-activated protein kinase kinase 6
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
NDRG1 N-myc downstream regulated 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NHEJ1 nonhomologous end-joining factor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORAI1 ORAI calcium release-activated calcium modulator 1
PERP PERP, TP53 apoptosis effector
PNP purine nucleoside phosphorylase
POLG polymerase (DNA directed), gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
SMAD3 SMAD family member 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TMEM109 transmembrane protein 109
TP53 tumor protein p53
TP73 tumor protein p73
TRAF2 TNF receptor-associated factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
WAS Wiskott-Aldrich syndrome
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa