abnormal thymus morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the primary lymphoid organ that is required for maturation of T cells (Mammalian Phenotype Ontology, MP_0000703)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000703
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Genes

343 gene mutations causing the abnormal thymus morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADRM1 adhesion regulating molecule 1
AFF1 AF4/FMR2 family, member 1
AIRE autoimmune regulator
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALPL alkaline phosphatase, liver/bone/kidney
ANK1 ankyrin 1, erythrocytic
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP1 Rho GTPase activating protein 1
ARHGAP5 Rho GTPase activating protein 5
ARID5B AT rich interactive domain 5B (MRF1-like)
ASL argininosuccinate lyase
ASXL1 additional sex combs like transcriptional regulator 1
ATCAY ataxia, cerebellar, Cayman type
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAG4 BCL2-associated athanogene 4
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BOK BCL2-related ovarian killer
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACYBP calcyclin binding protein
CARM1 coactivator-associated arginine methyltransferase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CCNB2 cyclin B2
CCND3 cyclin D3
CCR7 chemokine (C-C motif) receptor 7
CCR9 chemokine (C-C motif) receptor 9
CD247 CD247 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD5L CD5 molecule-like
CD7 CD7 molecule
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHD7 chromodomain helicase DNA binding protein 7
CHRD chordin
CISH cytokine inducible SH2-containing protein
CLEC4D C-type lectin domain family 4, member D
COL10A1 collagen, type X, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CORO1A coronin, actin binding protein, 1A
CREBBP CREB binding protein
CRIP3 cysteine-rich protein 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1 colony stimulating factor 1 (macrophage)
CTC1 CTS telomere maintenance complex component 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSD cathepsin D
CTSV cathepsin V
CUX1 cut-like homeobox 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYS1 cystin 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAD1 defender against cell death 1
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DFNB31 deafness, autosomal recessive 31
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DMTF1 cyclin D binding myb-like transcription factor 1
DNASE2 deoxyribonuclease II, lysosomal
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
ECE1 endothelin converting enzyme 1
EDNRA endothelin receptor type A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELAVL1 ELAV like RNA binding protein 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EP300 E1A binding protein p300
ERAP1 endoplasmic reticulum aminopeptidase 1
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EWSR1 EWS RNA-binding protein 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FES FES proto-oncogene, tyrosine kinase
FGF10 fibroblast growth factor 10
FGF23 fibroblast growth factor 23
FGFR2 fibroblast growth factor receptor 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FUS FUS RNA binding protein
FYB FYN binding protein
FZD9 frizzled class receptor 9
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GFI1 growth factor independent 1 transcription repressor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GLRA1 glycine receptor, alpha 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GRAP2 GRB2-related adaptor protein 2
HAX1 HCLS1 associated protein X-1
HELLS helicase, lymphoid-specific
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA1 homeobox A1
HOXA3 homeobox A3
HOXB9 homeobox B9
HR hair growth associated
HTRA2 HtrA serine peptidase 2
HYDIN HYDIN, axonemal central pair apparatus protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
ING1 inhibitor of growth family, member 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAG2 jagged 2
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0101 KIAA0101
KIFAP3 kinesin-associated protein 3
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLF13 Kruppel-like factor 13
KMT2E lysine (K)-specific methyltransferase 2E
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMA2 laminin, alpha 2
LAMP2 lysosomal-associated membrane protein 2
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LMNA lamin A/C
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LRP2 low density lipoprotein receptor-related protein 2
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAML1 mastermind-like 1 (Drosophila)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCM4 minichromosome maintenance complex component 4
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCOR1 nuclear receptor corepressor 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NLK nemo-like kinase
NOTCH1 notch 1
NOTCH3 notch 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PARL presenilin associated, rhomboid-like
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX1 paired box 1
PAX3 paired box 3
PAX9 paired box 9
PBX1 pre-B-cell leukemia homeobox 1
PCGF2 polycomb group ring finger 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PFDN1 prefoldin subunit 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIKFYVE phosphoinositide kinase, FYVE finger containing
PIP prolactin-induced protein
PKNOX1 PBX/knotted 1 homeobox 1
PLXND1 plexin D1
PNP purine nucleoside phosphorylase
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS16 protease, serine, 16 (thymus)
PTCRA pre T-cell antigen receptor alpha
PTEN phosphatase and tensin homolog
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RECQL4 RecQ protein-like 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOH ras homolog family member H
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPPLY3 ripply transcriptional repressor 3
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RPL27A ribosomal protein L27a
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RUVBL2 RuvB-like AAA ATPase 2
SAC3D1 SAC3 domain containing 1
SATB1 SATB homeobox 1
SELENBP1 selenium binding protein 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGPL1 sphingosine-1-phosphate lyase 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SIX1 SIX homeobox 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC46A2 solute carrier family 46, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOAT1 sterol O-acyltransferase 1
SOCS1 suppressor of cytokine signaling 1
SP3 Sp3 transcription factor
SP4 Sp4 transcription factor
SPI1 Spi-1 proto-oncogene
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
STK36 serine/threonine kinase 36
STK4 serine/threonine kinase 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYK spleen tyrosine kinase
T T, brachyury homolog (mouse)
TACC3 transforming, acidic coiled-coil containing protein 3
TBATA thymus, brain and testes associated
TBX1 T-box 1
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TDP2 tyrosyl-DNA phosphodiesterase 2
TESPA1 thymocyte expressed, positive selection associated 1
TET2 tet methylcytosine dioxygenase 2
TGM2 transglutaminase 2
THEMIS thymocyte selection associated
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAT1 T cell receptor associated transmembrane adaptor 1
TREX1 three prime repair exonuclease 1
TTC7A tetratricopeptide repeat domain 7A
TWIST2 twist family bHLH transcription factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
UNG uracil-DNA glycosylase
VAV1 vav 1 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
WNT1 wingless-type MMTV integration site family, member 1
WNT4 wingless-type MMTV integration site family, member 4
WWOX WW domain containing oxidoreductase
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZMPSTE24 zinc metallopeptidase STE24