abnormal tectorial membrane morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals (Mammalian Phenotype Ontology, MP_0003149)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003149
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Genes

28 gene mutations causing the abnormal tectorial membrane morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
COL11A2 collagen, type XI, alpha 2
COL9A1 collagen, type IX, alpha 1
DUOX2 dual oxidase 2
ESPN espin
GRXCR1 glutaredoxin, cysteine rich 1
HPN hepsin
IGF1 insulin-like growth factor 1 (somatomedin C)
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LOC102723475 putative uncharacterized protein LOC388820
MCOLN3 mucolipin 3
MYO6 myosin VI
OC90 otoconin 90
OTOA otoancorin
OTOG otogelin
PAX8 paired box 8
S1PR2 sphingosine-1-phosphate receptor 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC26A4 solute carrier family 26 (anion exchanger), member 4
TECTA tectorin alpha
TECTB tectorin beta
THRB thyroid hormone receptor, beta
TMC1 transmembrane channel-like 1
TMIE transmembrane inner ear
TPO thyroid peroxidase
TSHR thyroid stimulating hormone receptor