abnormal t-helper 1 physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal function of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity (Mammalian Phenotype Ontology, MP_0005465)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005465
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Genes

46 gene mutations causing the abnormal t-helper 1 physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
AIRE autoimmune regulator
CD247 CD247 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CIITA class II, major histocompatibility complex, transactivator
CRTAM cytotoxic and regulatory T cell molecule
CXCR2 chemokine (C-X-C motif) receptor 2
FLT3LG fms-related tyrosine kinase 3 ligand
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
HLA-DMA major histocompatibility complex, class II, DM alpha
IL12B interleukin 12B
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL27RA interleukin 27 receptor, alpha
IL6 interleukin 6
IRF5 interferon regulatory factor 5
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK14 mitogen-activated protein kinase 14
MOG myelin oligodendrocyte glycoprotein
MPZ myelin protein zero
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
PDLIM2 PDZ and LIM domain 2 (mystique)
POU2AF1 POU class 2 associating factor 1
PTX3 pentraxin 3, long
RAG2 recombination activating gene 2
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RIPK2 receptor-interacting serine-threonine kinase 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
STAT4 signal transducer and activator of transcription 4
TLR9 toll-like receptor 9
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM27 tripartite motif containing 27
TYK2 tyrosine kinase 2
ZBTB46 zinc finger and BTB domain containing 46