abnormal t follicular helper cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production (Mammalian Phenotype Ontology, MP_0010189)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010189
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Genes

2 gene mutations causing the abnormal t follicular helper cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD274 CD274 molecule
RC3H1 ring finger and CCCH-type domains 1