abnormal t cell selection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation (Mammalian Phenotype Ontology, MP_0004917)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004917
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Genes

23 gene mutations causing the abnormal t cell selection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD40LG CD40 ligand
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
FAS Fas cell surface death receptor
FYN FYN proto-oncogene, Src family tyrosine kinase
HLA-DMA major histocompatibility complex, class II, DM alpha
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
PRKCQ protein kinase C, theta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
THEMIS thymocyte selection associated
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa