abnormal t cell apoptosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description change in the timing or the number of T cells undergoing programmed cell death (Mammalian Phenotype Ontology, MP_0006412)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006412
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Genes

80 gene mutations causing the abnormal t cell apoptosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC6 baculoviral IAP repeat containing 6
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC86 coiled-coil domain containing 86
CD247 CD247 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CDK6 cyclin-dependent kinase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COPS6 COP9 signalosome subunit 6
CORO1A coronin, actin binding protein, 1A
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
DCK deoxycytidine kinase
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTX1 deltex 1, E3 ubiquitin ligase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAIM Fas apoptotic inhibitory molecule
FCMR Fc fragment of IgM receptor
FOXP3 forkhead box P3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAVCR2 hepatitis A virus cellular receptor 2
IL15RA interleukin 15 receptor, alpha
ING1 inhibitor of growth family, member 1
KIFAP3 kinesin-associated protein 3
KLF13 Kruppel-like factor 13
LCN2 lipocalin 2
LECT2 leukocyte cell-derived chemotaxin 2
LIG4 ligase IV, DNA, ATP-dependent
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MERTK MER proto-oncogene, tyrosine kinase
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHEJ1 nonhomologous end-joining factor 1
NOTCH1 notch 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PARL presenilin associated, rhomboid-like
PERP PERP, TP53 apoptosis effector
PKNOX1 PBX/knotted 1 homeobox 1
PNP purine nucleoside phosphorylase
PRF1 perforin 1 (pore forming protein)
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPRC protein tyrosine phosphatase, receptor type, C
RCAN1 regulator of calcineurin 1
RHOH ras homolog family member H
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RUNX1 runt-related transcription factor 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK4 serine/threonine kinase 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TMEM109 transmembrane protein 109
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53 tumor protein p53
TP73 tumor protein p73
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
USP4 ubiquitin specific peptidase 4 (proto-oncogene)