abnormal t cell activation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the process of producing effector T cells from naive T cells (Mammalian Phenotype Ontology, MP_0001828)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001828
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Genes

264 gene mutations causing the abnormal t cell activation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AHNAK AHNAK nucleoprotein
AIRE autoimmune regulator
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCL10 B-cell CLL/lymphoma 10
BCL2L1 BCL2-like 1
BCL6B B-cell CLL/lymphoma 6, member B
BCLAF1 BCL2-associated transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTLA B and T lymphocyte associated
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCND3 cyclin D3
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD151 CD151 molecule (Raph blood group)
CD1D CD1d molecule
CD226 CD226 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD5 CD5 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CD83 CD83 molecule
CD86 CD86 molecule
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CORO1A coronin, actin binding protein, 1A
CRH corticotropin releasing hormone
CRLF2 cytokine receptor-like factor 2
CRTAM cytotoxic and regulatory T cell molecule
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DBNL drebrin-like
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DOCK8 dedicator of cytokinesis 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTX1 deltex 1, E3 ubiquitin ligase
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELF4 E74-like factor 4 (ets domain transcription factor)
EPHB6 EPH receptor B6
ERAP1 endoplasmic reticulum aminopeptidase 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOXN1 forkhead box N1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC2 glucose-6-phosphatase, catalytic, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GFI1 growth factor independent 1 transcription repressor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR132 G protein-coupled receptor 132
GRAP GRB2-related adaptor protein
HAVCR2 hepatitis A virus cellular receptor 2
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-A major histocompatibility complex, class I, A
HLA-DMA major histocompatibility complex, class II, DM alpha
HR hair growth associated
HRH1 histamine receptor H1
HSH2D hematopoietic SH2 domain containing
ICOS inducible T-cell co-stimulator
IFNB1 interferon, beta 1, fibroblast
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL27RA interleukin 27 receptor, alpha
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL31RA interleukin 31 receptor A
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
JUND jun D proto-oncogene
KSR1 kinase suppressor of ras 1
LAPTM5 lysosomal protein transmembrane 5
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LAX1 lymphocyte transmembrane adaptor 1
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LY9 lymphocyte antigen 9
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MBP myelin basic protein
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
MTA2 metastasis associated 1 family, member 2
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NUP98 nucleoporin 98kDa
ORAI1 ORAI calcium release-activated calcium modulator 1
PAWR PRKC, apoptosis, WT1, regulator
PDCD1LG2 programmed cell death 1 ligand 2
PFDN1 prefoldin subunit 1
PGAP3 post-GPI attachment to proteins 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRF1 perforin 1 (pore forming protein)
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAG2 recombination activating gene 2
RAP1A RAP1A, member of RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOH ras homolog family member H
RIPK2 receptor-interacting serine-threonine kinase 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAC3D1 SAC3 domain containing 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SASH3 SAM and SH3 domain containing 3
SATB1 SATB homeobox 1
SELK selenoprotein K
SELL selectin L
SH2D1A SH2 domain containing 1A
SH2D2A SH2 domain containing 2A
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP1 src kinase associated phosphoprotein 1
SKIL SKI-like proto-oncogene
SMAD3 SMAD family member 3
SOX13 SRY (sex determining region Y)-box 13
SPN sialophorin
SPTA1 spectrin, alpha, erythrocytic 1
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
SUCNR1 succinate receptor 1
TBC1D10C TBC1 domain family, member 10C
TERC telomerase RNA component
TESPA1 thymocyte expressed, positive selection associated 1
THEMIS thymocyte selection associated
TIGIT T cell immunoreceptor with Ig and ITIM domains
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF5 TNF receptor-associated factor 5
TRIM21 tripartite motif containing 21
TSPAN32 tetraspanin 32
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB32 zinc finger and BTB domain containing 32
ZC3H12D zinc finger CCCH-type containing 12D