abnormal sternum morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the long flat bone of the chest that articulates with clavicle and first seven rib pairs; from rostral to caudal positions, the sternum consists of three parts: manubrium, body, and xiphoid process (Mammalian Phenotype Ontology, MP_0000157)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000157
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Genes

155 gene mutations causing the abnormal sternum morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AMER1 APC membrane recruitment protein 1
ARID5B AT rich interactive domain 5B (MRF1-like)
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRCA2 breast cancer 2, early onset
C5ORF42 chromosome 5 open reading frame 42
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CBFB core-binding factor, beta subunit
CBX2 chromobox homolog 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPJ centromere protein J
CHUK conserved helix-loop-helix ubiquitous kinase
COL27A1 collagen, type XXVII, alpha 1
CREBBP CREB binding protein
CSRNP1 cysteine-serine-rich nuclear protein 1
CTGF connective tissue growth factor
DCHS1 dachsous cadherin-related 1
DEAF1 DEAF1 transcription factor
DERL2 derlin 2
DLL3 delta-like 3 (Drosophila)
DMRT2 doublesex and mab-3 related transcription factor 2
DPPA4 developmental pluripotency associated 4
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB1 ephrin-B1
EN1 engrailed homeobox 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM134C family with sequence similarity 134, member C
FAT4 FAT atypical cadherin 4
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFRL1 fibroblast growth factor receptor-like 1
FLNA filamin A, alpha
FLNB filamin B, beta
FOXC1 forkhead box C1
FRAS1 Fraser extracellular matrix complex subunit 1
FST follistatin
FSTL1 follistatin-like 1
FUZ fuzzy planar cell polarity protein
GDF11 growth differentiation factor 11
GLCE glucuronic acid epimerase
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GPC3 glypican 3
GRHL2 grainyhead-like 2 (Drosophila)
GSC goosecoid homeobox
GSK3B glycogen synthase kinase 3 beta
HOXA10 homeobox A10
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB4 homeobox B4
HOXB7 homeobox B7
HOXB8 homeobox B8
HOXB9 homeobox B9
HOXC4 homeobox C4
HOXC8 homeobox C8
HOXC9 homeobox C9
HOXD3 homeobox D3
HOXD8 homeobox D8
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPB11 heat shock protein family B (small), member 11
HSPG2 heparan sulfate proteoglycan 2
IFT27 intraflagellar transport 27
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IMPAD1 inositol monophosphatase domain containing 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF6 interferon regulatory factor 6
JARID2 jumonji, AT rich interactive domain 2
KAT2A K(lysine) acetyltransferase 2A
KIF7 kinesin family member 7
KMT2A lysine (K)-specific methyltransferase 2A
LASP1 LIM and SH3 protein 1
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LMNA lamin A/C
LMO4 LIM domain only 4
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MDFI MyoD family inhibitor
MEF2C myocyte enhancer factor 2C
MEGF8 multiple EGF-like-domains 8
MKS1 Meckel syndrome, type 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MTF2 metal response element binding transcription factor 2
MYF5 myogenic factor 5
MYF6 myogenic factor 6 (herculin)
MYOG myogenin (myogenic factor 4)
NABP2 nucleic acid binding protein 2
NXN nucleoredoxin
PAX1 paired box 1
PCGF2 polycomb group ring finger 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PGAP1 post-GPI attachment to proteins 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PHC2 polyhomeotic homolog 2 (Drosophila)
PHF14 PHD finger protein 14
PKDCC protein kinase domain containing, cytoplasmic
PSEN1 presenilin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTCH1 patched 1
PTHLH parathyroid hormone-like hormone
RNF2 ring finger protein 2
RPL38 ribosomal protein L38
RPS7 ribosomal protein S7
RUNX2 runt-related transcription factor 2
SCHIP1 schwannomin interacting protein 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SGPL1 sphingosine-1-phosphate lyase 1
SH3PXD2B SH3 and PX domains 2B
SIK3 SIK family kinase 3
SIX1 SIX homeobox 1
SMAD3 SMAD family member 3
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SOX11 SRY (sex determining region Y)-box 11
SOX5 SRY (sex determining region Y)-box 5
SOX6 SRY (sex determining region Y)-box 6
SOX9 SRY (sex determining region Y)-box 9
SP3 Sp3 transcription factor
SSBP3 single stranded DNA binding protein 3
SULF1 sulfatase 1
SULF2 sulfatase 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAPT1 transmembrane anterior posterior transformation 1
TASP1 taspase, threonine aspartase, 1
TCF15 transcription factor 15 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB2 transforming growth factor, beta 2
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM107 transmembrane protein 107
TRAF4 TNF receptor-associated factor 4
TRPS1 trichorhinophalangeal syndrome I
TSHZ1 teashirt zinc finger homeobox 1
UNCX UNC homeobox
VANGL2 VANGL planar cell polarity protein 2
WDR19 WD repeat domain 19
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZBTB16 zinc finger and BTB domain containing 16
ZEB1 zinc finger E-box binding homeobox 1
ZFAND5 zinc finger, AN1-type domain 5