abnormal spleen white pulp morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies (Mammalian Phenotype Ontology, MP_0002357)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002357
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Genes

234 gene mutations causing the abnormal spleen white pulp morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
AHR aryl hydrocarbon receptor
AIRE autoimmune regulator
AKAP13 A kinase (PRKA) anchor protein 13
ALOX15 arachidonate 15-lipoxygenase
APCS amyloid P component, serum
APOE apolipoprotein E
ARHGAP1 Rho GTPase activating protein 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASL argininosuccinate lyase
ASXL1 additional sex combs like transcriptional regulator 1
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C5AR1 complement component 5a receptor 1
CACYBP calcyclin binding protein
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD22 CD22 molecule
CD28 CD28 molecule
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD84 CD84 molecule
CD86 CD86 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COMMD3-BMI1 COMMD3-BMI1 readthrough
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSD cathepsin D
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
DCC DCC netrin 1 receptor
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DIAPH1 diaphanous-related formin 1
DIDO1 death inducer-obliterator 1
DKC1 dyskeratosis congenita 1, dyskerin
DLK1 delta-like 1 homolog (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DTX1 deltex 1, E3 ubiquitin ligase
E2F2 E2F transcription factor 2
EPS15 epidermal growth factor receptor pathway substrate 15
ESR1 estrogen receptor 1
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FCAMR Fc receptor, IgA, IgM, high affinity
FCMR Fc fragment of IgM receptor
FEN1 flap structure-specific endonuclease 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
FZD9 frizzled class receptor 9
GABPB2 GA binding protein transcription factor, beta subunit 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GAPT GRB2-binding adaptor protein, transmembrane
GATA1 GATA binding protein 1 (globin transcription factor 1)
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GON4L gon-4-like (C. elegans)
GPC3 glypican 3
HAX1 HCLS1 associated protein X-1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL21 interleukin 21
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
IRF4 interferon regulatory factor 4
IRF8 interferon regulatory factor 8
ITFG2 integrin alpha FG-GAP repeat containing 2
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMP2 lysosomal-associated membrane protein 2
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALT1 MALT1 paracaspase
MAML1 mastermind-like 1 (Drosophila)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCO macrophage receptor with collagenous structure
MARK2 MAP/microtubule affinity-regulating kinase 2
MEFV Mediterranean fever
MFGE8 milk fat globule-EGF factor 8 protein
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MIR155 microRNA 155
MITF microphthalmia-associated transcription factor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCOA3 nuclear receptor coactivator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NKX2-3 NK2 homeobox 3
NOTCH2 notch 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
PARP14 poly (ADP-ribose) polymerase family, member 14
PCSK1 proprotein convertase subtilisin/kexin type 1
PFDN1 prefoldin subunit 1
PGAP3 post-GPI attachment to proteins 3
PI16 peptidase inhibitor 16
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKN1 protein kinase N1
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
POU2AF1 POU class 2 associating factor 1
PPT2 palmitoyl-protein thioesterase 2
PRF1 perforin 1 (pore forming protein)
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RAG2 recombination activating gene 2
RECQL4 RecQ protein-like 4
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
S1PR2 sphingosine-1-phosphate receptor 2
SASH3 SAM and SH3 domain containing 3
SCARF1 scavenger receptor class F, member 1
SELL selectin L
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFN stratifin
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS1 suppressor of cytokine signaling 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
T T, brachyury homolog (mouse)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERC telomerase RNA component
TGFBR3 transforming growth factor, beta receptor III
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREX1 three prime repair exonuclease 1
TRIP10 thyroid hormone receptor interactor 10
TTC7A tetratricopeptide repeat domain 7A
TWIST2 twist family bHLH transcription factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV2 vav 2 guanine nucleotide exchange factor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WAS Wiskott-Aldrich syndrome
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1
ZFPM1 zinc finger protein, FOG family member 1