abnormal spleen marginal zone morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens (Mammalian Phenotype Ontology, MP_0002362)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002362
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Genes

96 gene mutations causing the abnormal spleen marginal zone morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
AIRE autoimmune regulator
APOE apolipoprotein E
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL10 B-cell CLL/lymphoma 10
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
CD22 CD22 molecule
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYLD cylindromatosis (turban tumor syndrome)
DLK1 delta-like 1 homolog (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DTX1 deltex 1, E3 ubiquitin ligase
EPS15 epidermal growth factor receptor pathway substrate 15
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FEN1 flap structure-specific endonuclease 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXP3 forkhead box P3
FZD9 frizzled class receptor 9
GAPT GRB2-binding adaptor protein, transmembrane
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
HAX1 HCLS1 associated protein X-1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL2RB interleukin 2 receptor, beta
IRF8 interferon regulatory factor 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MAML1 mastermind-like 1 (Drosophila)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCO macrophage receptor with collagenous structure
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NKX2-3 NK2 homeobox 3
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
PARP14 poly (ADP-ribose) polymerase family, member 14
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PNP purine nucleoside phosphorylase
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRJ protein tyrosine phosphatase, receptor type, J
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS1 regulator of G-protein signaling 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SASH3 SAM and SH3 domain containing 3
SFN stratifin
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPPL2A signal peptide peptidase like 2A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
UNC93B1 unc-93 homolog B1 (C. elegans)
WAS Wiskott-Aldrich syndrome
ZEB1 zinc finger E-box binding homeobox 1