abnormal spleen b cell follicle morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur (Mammalian Phenotype Ontology, MP_0008470)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008470
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Genes

122 gene mutations causing the abnormal spleen b cell follicle morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AHR aryl hydrocarbon receptor
AKAP13 A kinase (PRKA) anchor protein 13
ALOX15 arachidonate 15-lipoxygenase
ASL argininosuccinate lyase
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BHLHE40 basic helix-loop-helix family, member e40
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C5AR1 complement component 5a receptor 1
CD19 CD19 molecule
CD28 CD28 molecule
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD84 CD84 molecule
CD86 CD86 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSD cathepsin D
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR5 chemokine (C-X-C motif) receptor 5
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DIAPH1 diaphanous-related formin 1
DLK1 delta-like 1 homolog (Drosophila)
DOCK8 dedicator of cytokinesis 8
EPS15 epidermal growth factor receptor pathway substrate 15
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FCAMR Fc receptor, IgA, IgM, high affinity
FEN1 flap structure-specific endonuclease 1
FOXP3 forkhead box P3
GABPB2 GA binding protein transcription factor, beta subunit 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPC3 glypican 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNB1 interferon, beta 1, fibroblast
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL21 interleukin 21
IL2RG interleukin 2 receptor, gamma
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MEFV Mediterranean fever
MFGE8 milk fat globule-EGF factor 8 protein
MIR155 microRNA 155
MITF microphthalmia-associated transcription factor
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCOA3 nuclear receptor coactivator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-3 NK2 homeobox 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PGAP3 post-GPI attachment to proteins 3
PI16 peptidase inhibitor 16
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
POU2AF1 POU class 2 associating factor 1
PPT2 palmitoyl-protein thioesterase 2
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S1PR2 sphingosine-1-phosphate receptor 2
SCARF1 scavenger receptor class F, member 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFN stratifin
SH2D1A SH2 domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS1 suppressor of cytokine signaling 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STK4 serine/threonine kinase 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERC telomerase RNA component
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TRIP10 thyroid hormone receptor interactor 10
TYROBP TYRO protein tyrosine kinase binding protein
VAV2 vav 2 guanine nucleotide exchange factor