abnormal sperm axoneme morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion (Mammalian Phenotype Ontology, MP_0009838)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009838
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Genes

17 gene mutations causing the abnormal sperm axoneme morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ENO4 enolase family member 4
FSHR follicle stimulating hormone receptor
KATNB1 katanin p80 (WD repeat containing) subunit B 1
MEIG1 meiosis/spermiogenesis associated 1
MNS1 meiosis-specific nuclear structural 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
ODF2 outer dense fiber of sperm tails 2
PLA2G3 phospholipase A2, group III
SPAG16 sperm associated antigen 16
SPAG6 sperm associated antigen 6
SPEF2 sperm flagellar 2
TEKT2 tektin 2 (testicular)
THEG theg spermatid protein
TNP2 transition protein 2 (during histone to protamine replacement)
TPGS1 tubulin polyglutamylase complex subunit 1
TTLL5 tubulin tyrosine ligase-like family member 5
VDAC3 voltage-dependent anion channel 3