abnormal somite border morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap (Mammalian Phenotype Ontology, MP_0012728)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012728
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Genes

6 gene mutations causing the abnormal somite border morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CFL1 cofilin 1 (non-muscle)
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
PAX3 paired box 3