abnormal social investigation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description altered behavior of animals to approach and examine other animals (Mammalian Phenotype Ontology, MP_0001360)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001360
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Genes

68 gene mutations causing the abnormal social investigation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
C12ORF10 chromosome 12 open reading frame 10
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CADPS2 Ca++-dependent secretion activator 2
CDKL5 cyclin-dependent kinase-like 5
CENPJ centromere protein J
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CNTNAP2 contactin associated protein-like 2
CRHR2 corticotropin releasing hormone receptor 2
CSK c-src tyrosine kinase
DISC1 disrupted in schizophrenia 1
DLG4 discs, large homolog 4 (Drosophila)
DOCK7 dedicator of cytokinesis 7
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EN2 engrailed homeobox 2
ESR1 estrogen receptor 1
FMR1 fragile X mental retardation 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRN granulin
GRPR gastrin-releasing peptide receptor
IL6 interleukin 6
LPAR5 lysophosphatidic acid receptor 5
LRRTM1 leucine rich repeat transmembrane neuronal 1
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MAP6 microtubule-associated protein 6
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MCHR1 melanin-concentrating hormone receptor 1
MDK midkine (neurite growth-promoting factor 2)
MECP2 methyl CpG binding protein 2
NAT8L N-acetyltransferase 8-like (GCN5-related, putative)
NBEA neurobeachin
NIPAL3 NIPA-like domain containing 3
NLGN3 neuroligin 3
NPAS3 neuronal PAS domain protein 3
NRCAM neuronal cell adhesion molecule
OPRM1 opioid receptor, mu 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
PDE10A phosphodiesterase 10A
PDE11A phosphodiesterase 11A
PINK1 PTEN induced putative kinase 1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
RLN3 relaxin 3
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRR serine racemase
STX1A syntaxin 1A (brain)
SYN1 synapsin I
SYN2 synapsin II
SYN3 synapsin III
SYNGAP1 synaptic Ras GTPase activating protein 1
UCN3 urocortin 3
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)