abnormal small intestine crypts of lieberkuhn morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the parallel, tubular, epithelial pits (crypts) with openings at the bases of the small intestinal villi; their thin walls are formed by columnar epithelial cells: mostly undifferentiated stem and intermediate cells and an increasing number of mucus-secreting goblet cells as the small intestine proceeds distally, all of which migrate out of the glands onto the villi, but also protein- (enzyme-) secreting Paneth cells that remain in the glands (Mammalian Phenotype Ontology, MP_0004841)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004841
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Genes

26 gene mutations causing the abnormal small intestine crypts of lieberkuhn morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGR2 anterior gradient 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL2 B-cell CLL/lymphoma 2
CA9 carbonic anhydrase IX
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLDN15 claudin 15
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7
FEN1 flap structure-specific endonuclease 1
FGF9 fibroblast growth factor 9
FOXL1 forkhead box L1
GPX1 glutathione peroxidase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
MCM2 minichromosome maintenance complex component 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX2-3 NK2 homeobox 3
NRIP1 nuclear receptor interacting protein 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RC3H1 ring finger and CCCH-type domains 1
SEC23B Sec23 homolog B (S. cerevisiae)
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPDEF SAM pointed domain containing ETS transcription factor
STX2 syntaxin 2
YIPF6 Yip1 domain family, member 6