abnormal single-positive t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface (Mammalian Phenotype Ontology, MP_0008081)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008081
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Genes

54 gene mutations causing the abnormal single-positive t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADRM1 adhesion regulating molecule 1
AFF1 AF4/FMR2 family, member 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD247 CD247 molecule
CDK6 cyclin-dependent kinase 6
COL10A1 collagen, type X, alpha 1
CRLF2 cytokine receptor-like factor 2
DIAPH1 diaphanous-related formin 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
FOXN1 forkhead box N1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HAX1 HCLS1 associated protein X-1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTRA2 HtrA serine peptidase 2
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
LAG3 lymphocyte-activation gene 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MCL1 myeloid cell leukemia 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
PKNOX1 PBX/knotted 1 homeobox 1
PNP purine nucleoside phosphorylase
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOH ras homolog family member H
RUNX1 runt-related transcription factor 1
SGPL1 sphingosine-1-phosphate lyase 1
SPNS2 spinster homolog 2 (Drosophila)
STK4 serine/threonine kinase 4
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
THEMIS thymocyte selection associated
TPP2 tripeptidyl peptidase II
TWSG1 twisted gastrulation BMP signaling modulator 1
VAV1 vav 1 guanine nucleotide exchange factor
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1
ZNF335 zinc finger protein 335