abnormal response to injury Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the body's reaction to trauma, especially that by physical means (Mammalian Phenotype Ontology, MP_0005164)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005164
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Genes

405 gene mutations causing the abnormal response to injury phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABHD2 abhydrolase domain containing 2
ABRA actin binding Rho activating protein
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
AEBP1 AE binding protein 1
AGER advanced glycosylation end product-specific receptor
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AK1 adenylate kinase 1
ANXA1 annexin A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLN apelin
APOA1 apolipoprotein A-I
APOD apolipoprotein D
APOE apolipoprotein E
AQP4 aquaporin 4
ARHGAP1 Rho GTPase activating protein 1
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ASPH aspartate beta-hydroxylase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BBC3 BCL2 binding component 3
BECN1 beclin 1, autophagy related
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BNC1 basonuclin 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BVES blood vessel epicardial substance
C3 complement component 3
C5 complement component 5
C6 complement component 6
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMTA2 calmodulin binding transcription activator 2
CAPN8 calpain 8
CAPN9 calpain 9
CASQ2 calsequestrin 2 (cardiac muscle)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCM2L cerebral cavernous malformation 2-like
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD19 CD19 molecule
CD1D CD1d molecule
CD274 CD274 molecule
CD2AP CD2-associated protein
CD300A CD300a molecule
CD300LB CD300 molecule-like family member b
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFP complement factor properdin
CGN cingulin
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CLIC4 chloride intracellular channel 4
CLOCK clock circadian regulator
CNN1 calponin 1, basic, smooth muscle
CNN2 calponin 2
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COL13A1 collagen, type XIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL9A1 collagen, type IX, alpha 1
CP ceruloplasmin (ferroxidase)
CPB2 carboxypeptidase B2 (plasma)
CR1L complement component (3b/4b) receptor 1-like
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CST3 cystatin C
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CYR61 cysteine-rich, angiogenic inducer, 61
CYSLTR2 cysteinyl leukotriene receptor 2
DAAM1 dishevelled associated activator of morphogenesis 1
DACT2 dishevelled-binding antagonist of beta-catenin 2
DACT3 dishevelled-binding antagonist of beta-catenin 3
DAPK1 death-associated protein kinase 1
DCR Down syndrome chromosome region
DDIT3 DNA-damage-inducible transcript 3
DDR2 discoidin domain receptor tyrosine kinase 2
DLC1 DLC1 Rho GTPase activating protein
DST dystonin
DUSP6 dual specificity phosphatase 6
EGLN1 egl-9 family hypoxia-inducible factor 1
EGR1 early growth response 1
ELN elastin
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
EPPK1 epiplakin 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F9 coagulation factor IX
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAIM2 Fas apoptotic inhibitory molecule 2
FAM132B family with sequence similarity 132, member B
FASLG Fas ligand (TNF superfamily, member 6)
FBLN5 fibulin 5
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCMR Fc fragment of IgM receptor
FGA fibrinogen alpha chain
FGF2 fibroblast growth factor 2 (basic)
FHL1 four and a half LIM domains 1
FLII flightless I homolog (Drosophila)
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FPR2 formyl peptide receptor 2
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GATA4 GATA binding protein 4
GDF15 growth differentiation factor 15
GFAP glial fibrillary acidic protein
GIPC1 GIPC PDZ domain containing family, member 1
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GJB3 gap junction protein, beta 3, 31kDa
GLP1R glucagon-like peptide 1 receptor
GLRX3 glutaredoxin 3
GNRHR gonadotropin-releasing hormone receptor
GPR180 G protein-coupled receptor 180
GPR22 G protein-coupled receptor 22
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRID2 glutamate receptor, ionotropic, delta 2
GRK5 G protein-coupled receptor kinase 5
GRM1 glutamate receptor, metabotropic 1
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HABP2 hyaluronan binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRC histidine rich calcium binding protein
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IL10 interleukin 10
IL13 interleukin 13
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
IL27RA interleukin 27 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
INPP5F inositol polyphosphate-5-phosphatase F
IRF1 interferon regulatory factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA1 integrin, alpha 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
JDP2 Jun dimerization protein 2
JUND jun D proto-oncogene
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF15 Kruppel-like factor 15
KLF5 Kruppel-like factor 5 (intestinal)
KLHL20 kelch-like family member 20
KRT6B keratin 6B, type II
LBP lipopolysaccharide binding protein
LDB3 LIM domain binding 3
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LIMS2 LIM and senescent cell antigen-like domains 2
LITAF lipopolysaccharide-induced TNF factor
LPP LIM domain containing preferred translocation partner in lipoma
LTA lymphotoxin alpha
LUM lumican
MAOA monoamine oxidase A
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MASP2 mannan-binding lectin serine peptidase 2
MDK midkine (neurite growth-promoting factor 2)
MEP1B meprin A, beta
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
MGMT O-6-methylguanine-DNA methyltransferase
MIR143 microRNA 143
MIR22 microRNA 22
MLKL mixed lineage kinase domain-like
MMP11 matrix metallopeptidase 11
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MURC muscle-related coiled-coil protein
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYH11 myosin, heavy chain 11, smooth muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK myosin light chain kinase
MYLK3 myosin light chain kinase 3
MYOZ2 myozenin 2
NAMPT nicotinamide phosphoribosyltransferase
NBEAL2 neurobeachin-like 2
NCF1 neutrophil cytosolic factor 1
NCOA6 nuclear receptor coactivator 6
NDRG4 NDRG family member 4
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK6 NIMA-related kinase 6
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2L2 nuclear factor, erythroid 2-like 2
NGFR nerve growth factor receptor
NLRP1 NLR family, pyrin domain containing 1
NLRP6 NLR family, pyrin domain containing 6
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NONO non-POU domain containing, octamer-binding
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NOV nephroblastoma overexpressed
NOX4 NADPH oxidase 4
NPAS2 neuronal PAS domain protein 2
NPR1 natriuretic peptide receptor 1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM1 olfactomedin 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OMG oligodendrocyte myelin glycoprotein
PANX1 pannexin 1
PANX2 pannexin 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PENK proenkephalin
PGF placental growth factor
PGR progesterone receptor
PLA2G10 phospholipase A2, group X
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G5 phospholipase A2, group V
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCE1 phospholipase C, epsilon 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEC plectin
PLG plasminogen
POPDC2 popeye domain containing 2
POSTN periostin, osteoblast specific factor
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRMT2 protein arginine methyltransferase 2
PRSS8 protease, serine, 8
PSPN persephin
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCAN1 regulator of calcineurin 1
RDH13 retinol dehydrogenase 13 (all-trans/9-cis)
REG1B regenerating islet-derived 1 beta
RETNLB resistin like beta
RFX4 regulatory factor X, 4 (influences HLA class II expression)
RNLS renalase, FAD-dependent amine oxidase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAS related RAS viral (r-ras) oncogene homolog
RTN4R reticulon 4 receptor
RYR2 ryanodine receptor 2 (cardiac)
SCARB1 scavenger receptor class B, member 1
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SDC4 syndecan 4
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP2 secreted frizzled-related protein 2
SFTPB surfactant protein B
SIRT7 sirtuin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNTA1 syntrophin, alpha 1
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SOD3 superoxide dismutase 3, extracellular
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SSPN sarcospan
SSTR2 somatostatin receptor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STIM2 stromal interaction molecule 2
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUCO SUN domain containing ossification factor
TCAP titin-cap
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
THBD thrombomodulin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TICAM1 toll-like receptor adaptor molecule 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TREM1 triggering receptor expressed on myeloid cells 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSC2 tuberous sclerosis 2
TXNIP thioredoxin interacting protein
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UHMK1 U2AF homology motif (UHM) kinase 1
UNG uracil-DNA glycosylase
VEGFB vascular endothelial growth factor B
VIL1 villin 1
VTN vitronectin
VWF von Willebrand factor
WDR83 WD repeat domain 83
WWTR1 WW domain containing transcription regulator 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZEB1 zinc finger E-box binding homeobox 1