abnormal renal glomerulus morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit (Mammalian Phenotype Ontology, MP_0005325)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005325
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Genes

215 gene mutations causing the abnormal renal glomerulus morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACE angiotensin I converting enzyme
ACTN4 actinin, alpha 4
ADM adrenomedullin
AGA aspartylglucosaminidase
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANK1 ankyrin 1, erythrocytic
APCS amyloid P component, serum
APOE apolipoprotein E
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID5B AT rich interactive domain 5B (MRF1-like)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASIP agouti signaling protein
ASL argininosuccinate lyase
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BAG6 BCL2-associated athanogene 6
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BDKRB2 bradykinin receptor B2
BHLHE40 basic helix-loop-helix family, member e40
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BMPER BMP binding endothelial regulator
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CCNI cyclin I
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CD151 CD151 molecule (Raph blood group)
CD1D CD1d molecule
CD2AP CD2-associated protein
CD72 CD72 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CFI complement factor I
CHD2 chromodomain helicase DNA binding protein 2
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COMT catechol-O-methyltransferase
CORO1A coronin, actin binding protein, 1A
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DKC1 dyskeratosis congenita 1, dyskerin
DLG1 discs, large homolog 1 (Drosophila)
DNASE1 deoxyribonuclease I
DTX1 deltex 1, E3 ubiquitin ligase
E2F2 E2F transcription factor 2
ESR1 estrogen receptor 1
ESRRG estrogen-related receptor gamma
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLN1 fibulin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGF23 fibroblast growth factor 23
FGFR2 fibroblast growth factor receptor 2
FOXC2 forkhead box C2
FOXD1 forkhead box D1
FRAS1 Fraser extracellular matrix complex subunit 1
G6PC glucose-6-phosphatase, catalytic subunit
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GDNF glial cell derived neurotrophic factor
GLB1 galactosidase, beta 1
GLIS2 GLIS family zinc finger 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLM1 golgi membrane protein 1
GPR4 G protein-coupled receptor 4
GPX7 glutathione peroxidase 7
GRM1 glutamate receptor, metabotropic 1
GSTK1 glutathione S-transferase kappa 1
GUSB glucuronidase, beta
HMOX1 heme oxygenase 1
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HR hair growth associated
IFNG interferon, gamma
IFT172 intraflagellar transport 172
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL12RB2 interleukin 12 receptor, beta 2
INS insulin
INVS inversin
ITGA1 integrin, alpha 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAK1 Janus kinase 1
KIRREL kin of IRRE like (Drosophila)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMA5 laminin, alpha 5
LAMB2 laminin, beta 2 (laminin S)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAT linker for activation of T cells
LCAT lecithin-cholesterol acyltransferase
LEP leptin
LEPR leptin receptor
LGMN legumain
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMK2 LIM domain kinase 2
LMX1B LIM homeobox transcription factor 1, beta
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS2 leucine zipper, putative tumor suppressor 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2A1 mannosidase, alpha, class 2A, member 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MGP matrix Gla protein
MIR192 microRNA 192
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPV17 MpV17 mitochondrial inner membrane protein
MTA2 metastasis associated 1 family, member 2
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYH9 myosin, heavy chain 9, non-muscle
MYO1E myosin IE
NCKAP1L NCK-associated protein 1-like
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR3C2 nuclear receptor subfamily 3, group C, member 2
PAX2 paired box 2
PBX1 pre-B-cell leukemia homeobox 1
PDCD1 programmed cell death 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDS5A PDS5 cohesin associated factor A
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEX13 peroxisomal biogenesis factor 13
PGAP3 post-GPI attachment to proteins 3
PGM3 phosphoglucomutase 3
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKN1 protein kinase N1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLB polymerase (DNA directed), beta
PRDX6 peroxiredoxin 6
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRO protein tyrosine phosphatase, receptor type, O
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REN renin
RET ret proto-oncogene
RPL22 ribosomal protein L22
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SALL1 spalt-like transcription factor 1
SCARF1 scavenger receptor class F, member 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCTR secretin receptor
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGPL1 sphingosine-1-phosphate lyase 1
SIAE sialic acid acetylesterase
SIRT1 sirtuin 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
STAG1 stromal antigen 1
SUCO SUN domain containing ossification factor
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TANK TRAF family member-associated NFKB activator
TCF21 transcription factor 21
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TK1 thymidine kinase 1, soluble
TLR8 toll-like receptor 8
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TNS2 tensin 2
TOP3B topoisomerase (DNA) III beta
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TROVE2 TROVE domain family, member 2
TRPS1 trichorhinophalangeal syndrome I
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUSC2 tumor suppressor candidate 2
UNC93B1 unc-93 homolog B1 (C. elegans)
UOX urate oxidase, pseudogene
UROS uroporphyrinogen III synthase
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WNT11 wingless-type MMTV integration site family, member 11
WNT4 wingless-type MMTV integration site family, member 4
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1
XDH xanthine dehydrogenase
ZDHHC13 zinc finger, DHHC-type containing 13
ZFP36 ZFP36 ring finger protein