abnormal professional antigen presenting cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response (Mammalian Phenotype Ontology, MP_0002452)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002452
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Genes

759 gene mutations causing the abnormal professional antigen presenting cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACP5 acid phosphatase 5, tartrate resistant
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
ADCY9 adenylate cyclase 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRE1 adhesion G protein-coupled receptor E1
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APLF aprataxin and PNKP like factor
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOE apolipoprotein E
ARG1 arginase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF3 activating transcription factor 3
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
AVPR1A arginine vasopressin receptor 1A
AZI2 5-azacytidine induced 2
B2M beta-2-microglobulin
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAD BCL2-associated agonist of cell death
BAG4 BCL2-associated athanogene 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BATF basic leucine zipper transcription factor, ATF-like
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBS4 Bardet-Biedl syndrome 4
BBX bobby sox homolog (Drosophila)
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BMF Bcl2 modifying factor
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1QBP complement component 1, q subcomponent binding protein
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3AR1 complement component 3a receptor 1
CABIN1 calcineurin binding protein 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAPG capping protein (actin filament), gelsolin-like
CARD11 caspase recruitment domain family, member 11
CARD9 caspase recruitment domain family, member 9
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCBE1 collagen and calcium binding EGF domains 1
CCDC171 coiled-coil domain containing 171
CCL13 chemokine (C-C motif) ligand 13
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCND3 cyclin D3
CCR1 chemokine (C-C motif) receptor 1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD14 CD14 molecule
CD180 CD180 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD200 CD200 molecule
CD200R1 CD200 receptor 1
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD300C CD300c molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD68 CD68 molecule
CD69 CD69 molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD80 CD80 molecule
CD81 CD81 molecule
CD83 CD83 molecule
CD84 CD84 molecule
CD86 CD86 molecule
CD93 CD93 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CH25H cholesterol 25-hydroxylase
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CIITA class II, major histocompatibility complex, transactivator
CLCN2 chloride channel, voltage-sensitive 2
CLCN3 chloride channel, voltage-sensitive 3
CLCN7 chloride channel, voltage-sensitive 7
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC4F C-type lectin domain family 4, member F
CLEC6A C-type lectin domain family 6, member A
CLEC7A C-type lectin domain family 7, member A
CLEC9A C-type lectin domain family 9, member A
CLIC4 chloride intracellular channel 4
CLK1 CDC-like kinase 1
CLUAP1 clusterin associated protein 1
CMKLR1 chemerin chemokine-like receptor 1
CNN2 calponin 2
CNPY3 canopy FGF signaling regulator 3
CNR2 cannabinoid receptor 2 (macrophage)
COL1A1 collagen, type I, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CORO1A coronin, actin binding protein, 1A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRH corticotropin releasing hormone
CRLF2 cytokine receptor-like factor 2
CRY2 cryptochrome circadian clock 2
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSE cathepsin E
CTSK cathepsin K
CTSS cathepsin S
CTSV cathepsin V
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYLD cylindromatosis (turban tumor syndrome)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNL drebrin-like
DCLRE1C DNA cross-link repair 1C
DCSTAMP dendrocyte expressed seven transmembrane protein
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DHRS4 dehydrogenase/reductase (SDR family) member 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK3 dedicator of cytokinesis 3
DOCK8 dedicator of cytokinesis 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSG3 desmoglein 3
DSG4 desmoglein 4
DTX1 deltex 1, E3 ubiquitin ligase
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
EBF1 early B-cell factor 1
ECM1 extracellular matrix protein 1
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF4 E74-like factor 4 (ets domain transcription factor)
ERCC1 excision repair cross-complementation group 1
ERO1L ERO1-like (S. cerevisiae)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXO1 exonuclease 1
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FADS2 fatty acid desaturase 2
FAIM Fas apoptotic inhibitory molecule
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLIM1 filamin binding LIM protein 1
FCAMR Fc receptor, IgA, IgM, high affinity
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCMR Fc fragment of IgM receptor
FCRLA Fc receptor-like A
FCRLB Fc receptor-like B
FES FES proto-oncogene, tyrosine kinase
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FLG filaggrin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
FOXN1 forkhead box N1
FOXP1 forkhead box P1
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FSCN1 fascin actin-bundling protein 1
FUS FUS RNA binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB2 GA binding protein transcription factor, beta subunit 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GAP43 growth associated protein 43
GAPT GRB2-binding adaptor protein, transmembrane
GBP3 guanylate binding protein 3
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GLB1 galactosidase, beta 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GON4L gon-4-like (C. elegans)
GPR132 G protein-coupled receptor 132
GPR183 G protein-coupled receptor 183
GPR55 G protein-coupled receptor 55
GPR65 G protein-coupled receptor 65
GPR68 G protein-coupled receptor 68
GRK6 G protein-coupled receptor kinase 6
GRN granulin
GSN gelsolin
H2AFX H2A histone family, member X
HAVCR1 hepatitis A virus cellular receptor 1
HAX1 HCLS1 associated protein X-1
HCK HCK proto-oncogene, Src family tyrosine kinase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HCST hematopoietic cell signal transducer
HDAC6 histone deacetylase 6
HEXB hexosaminidase B (beta polypeptide)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC4 homeobox C4
HPS1 Hermansky-Pudlak syndrome 1
HR hair growth associated
HRH1 histamine receptor H1
HRH4 histamine receptor H4
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HVCN1 hydrogen voltage gated channel 1
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IDUA iduronidase, alpha-L-
IER3 immediate early response 3
IFI30 interferon, gamma-inducible protein 30
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHD immunoglobulin heavy constant delta
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL17RB interleukin 17 receptor B
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL31RA interleukin 31 receptor A
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
IRF8 interferon regulatory factor 8
IRS1 insulin receptor substrate 1
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAD integrin, alpha D
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK1 Janus kinase 1
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDM8 lysine (K)-specific demethylase 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMA2 laminin, alpha 2
LAT linker for activation of T cells
LAX1 lymphocyte transmembrane adaptor 1
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LECT1 leukocyte cell derived chemotaxin 1
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LGMN legumain
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LIMD1 LIM domains containing 1
LITAF lipopolysaccharide-induced TNF factor
LPAR2 lysophosphatidic acid receptor 2
LRRK1 leucine-rich repeat kinase 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTB4R leukotriene B4 receptor
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LY86 lymphocyte antigen 86
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MALT1 MALT1 paracaspase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MARCKSL1 MARCKS-like 1
MARCO macrophage receptor with collagenous structure
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
MCAM melanoma cell adhesion molecule
MCOLN1 mucolipin 1
MDC1 mediator of DNA-damage checkpoint 1
MDK midkine (neurite growth-promoting factor 2)
MEFV Mediterranean fever
MEPE matrix extracellular phosphoglycoprotein
MFGE8 milk fat globule-EGF factor 8 protein
MINA MYC induced nuclear antigen
MIR150 microRNA 150
MIR155 microRNA 155
MITF microphthalmia-associated transcription factor
MLKL mixed lineage kinase domain-like
MMP12 matrix metallopeptidase 12
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP28 matrix metallopeptidase 28
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPZ myelin protein zero
MR1 major histocompatibility complex, class I-related
MRC1 mannose receptor, C type 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MSR1 macrophage scavenger receptor 1
MST1 macrophage stimulating 1
MST1R macrophage stimulating 1 receptor
MTA3 metastasis associated 1 family, member 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXD1 MAX dimerization protein 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYD88 myeloid differentiation primary response 88
MYO1G myosin IG
MYO6 myosin VI
MYO9B myosin IXB
MYSM1 Myb-like, SWIRM and MPN domains 1
NBR1 neighbor of BRCA1 gene 1
NCEH1 neutral cholesterol ester hydrolase 1
NCF1 neutrophil cytosolic factor 1
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NHEJ1 nonhomologous end-joining factor 1
NINJ1 ninjurin 1
NIPAL3 NIPA-like domain containing 3
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NLRP10 NLR family, pyrin domain containing 10
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NLRX1 NLR family member X1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NPY1R neuropeptide Y receptor Y1
NRP1 neuropilin 1
NUP98 nucleoporin 98kDa
ORAI1 ORAI calcium release-activated calcium modulator 1
OTUD7B OTU deubiquitinase 7B
OXSR1 oxidative stress responsive 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PARP1 poly (ADP-ribose) polymerase 1
PARP14 poly (ADP-ribose) polymerase family, member 14
PAWR PRKC, apoptosis, WT1, regulator
PAX5 paired box 5
PCTP phosphatidylcholine transfer protein
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PELI1 pellino E3 ubiquitin protein ligase 1
PELI3 pellino E3 ubiquitin protein ligase family member 3
PFDN1 prefoldin subunit 1
PGAP3 post-GPI attachment to proteins 3
PGLYRP2 peptidoglycan recognition protein 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGR polymeric immunoglobulin receptor
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITX3 paired-like homeodomain 3
PKN1 protein kinase N1
PLA2G10 phospholipase A2, group X
PLA2G15 phospholipase A2, group XV
PLA2G2D phospholipase A2, group IID
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G5 phospholipase A2, group V
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
PLEC plectin
PLG plasminogen
PLXNA1 plexin A1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
POLH polymerase (DNA directed), eta
POLM polymerase (DNA directed), mu
POLQ polymerase (DNA directed), theta
POMT1 protein-O-mannosyltransferase 1
PON2 paraoxonase 2
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPT1 palmitoyl-protein thioesterase 1
PRAP1 proline-rich acidic protein 1
PRF1 perforin 1 (pore forming protein)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT8 protein arginine methyltransferase 8
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PSAP prosaposin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGDR2 prostaglandin D2 receptor 2
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRE protein tyrosine phosphatase, receptor type, E
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
PVR poliovirus receptor
PYCARD PYD and CARD domain containing
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RAP1A RAP1A, member of RAS oncogene family
RASA4 RAS p21 protein activator 4
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RC3H2 ring finger and CCCH-type domains 2
RCAN1 regulator of calcineurin 1
REG3G regenerating islet-derived 3 gamma
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RHBDD3 rhomboid domain containing 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOG ras homolog family member G
RIF1 replication timing regulatory factor 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RORA RAR-related orphan receptor A
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX3 runt-related transcription factor 3
RUVBL2 RuvB-like AAA ATPase 2
RXRA retinoid X receptor, alpha
S100A4 S100 calcium binding protein A4
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
SAC3D1 SAC3 domain containing 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SARM1 sterile alpha and TIR motif containing 1
SASH3 SAM and SH3 domain containing 3
SBNO2 strawberry notch homolog 2 (Drosophila)
SCARF1 scavenger receptor class F, member 1
SDC1 syndecan 1
SELK selenoprotein K
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERTAD2 SERTA domain containing 2
SFN stratifin
SFTPD surfactant protein D
SGMS2 sphingomyelin synthase 2
SH2B2 SH2B adaptor protein 2
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIAE sialic acid acetylesterase
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIGLEC10 sialic acid binding Ig-like lectin 10
SIGLEC9 sialic acid binding Ig-like lectin 9
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SKAP2 src kinase associated phosphoprotein 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF8 SLAM family member 8
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNX5 sorting nexin 5
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SPHK2 sphingosine kinase 2
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPIC Spi-C transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SPPL2A signal peptide peptidase like 2A
SPTA1 spectrin, alpha, erythrocytic 1
SQSTM1 sequestosome 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SUCNR1 succinate receptor 1
SUCO SUN domain containing ossification factor
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TANK TRAF family member-associated NFKB activator
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D10C TBC1 domain family, member 10C
TBK1 TANK-binding kinase 1
TBX21 T-box 21
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERC telomerase RNA component
TGFB2 transforming growth factor, beta 2
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TICAM1 toll-like receptor adaptor molecule 1
TIGIT T cell immunoreceptor with Ig and ITIM domains
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TMEM173 transmembrane protein 173
TMEM79 transmembrane protein 79
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TNIP2 TNFAIP3 interacting protein 2
TOB2 transducer of ERBB2, 2
TP53BP1 tumor protein p53 binding protein 1
TRADD TNFRSF1A-associated via death domain
TRAF3IP2 TRAF3 interacting protein 2
TRAF4 TNF receptor-associated factor 4
TRAF5 TNF receptor-associated factor 5
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREX1 three prime repair exonuclease 1
TRIP10 thyroid hormone receptor interactor 10
TROVE2 TROVE domain family, member 2
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TSLP thymic stromal lymphopoietin
TUB tubby bipartite transcription factor
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
UNG uracil-DNA glycosylase
UXS1 UDP-glucuronate decarboxylase 1
VAMP8 vesicle-associated membrane protein 8
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIPR2 vasoactive intestinal peptide receptor 2
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WDR1 WD repeat domain 1
WIPF1 WAS/WASL interacting protein family, member 1
WWOX WW domain containing oxidoreductase
XCR1 chemokine (C motif) receptor 1
XPA xeroderma pigmentosum, complementation group A
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB46 zinc finger and BTB domain containing 46
ZC3H12A zinc finger CCCH-type containing 12A
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZNF318 zinc finger protein 318