abnormal pro-b cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs (Mammalian Phenotype Ontology, MP_0005432)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005432
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Genes

66 gene mutations causing the abnormal pro-b cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP11C ATPase, class VI, type 11C
BAD BCL2-associated agonist of cell death
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CCR9 chemokine (C-C motif) receptor 9
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDH17 cadherin 17, LI cadherin (liver-intestine)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
EBF1 early B-cell factor 1
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXO7 F-box protein 7
FES FES proto-oncogene, tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FZD9 frizzled class receptor 9
GON4L gon-4-like (C. elegans)
HAX1 HCLS1 associated protein X-1
HTRA2 HtrA serine peptidase 2
IFNB1 interferon, beta 1, fibroblast
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2 interleukin 2
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KAT6A K(lysine) acetyltransferase 6A
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLK nemo-like kinase
PAX5 paired box 5
PGM3 phosphoglucomutase 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SH3BP2 SH3-domain binding protein 2
SOX4 SRY (sex determining region Y)-box 4
SPI1 Spi-1 proto-oncogene
SYK spleen tyrosine kinase
TAC4 tachykinin 4 (hemokinin)
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF4 transcription factor 4
TET2 tet methylcytosine dioxygenase 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TSHR thyroid stimulating hormone receptor
TWSG1 twisted gastrulation BMP signaling modulator 1
ZBTB7A zinc finger and BTB domain containing 7A