abnormal primitive streak formation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm (Mammalian Phenotype Ontology, MP_0002230)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002230
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Genes

52 gene mutations causing the abnormal primitive streak formation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
AMN amnion associated transmembrane protein
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
CHD8 chromodomain helicase DNA binding protein 8
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FGFR1 fibroblast growth factor receptor 1
FOXA2 forkhead box A2
FOXD3 forkhead box D3
GDF3 growth differentiation factor 3
HNF4A hepatocyte nuclear factor 4, alpha
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
LDB1 LIM domain binding 1
LHX1 LIM homeobox 1
MACF1 microtubule-actin crosslinking factor 1
MESDC2 mesoderm development candidate 2
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
MYL1 myosin, light chain 1, alkali; skeletal, fast
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NCKAP1 NCK-associated protein 1
NFE2L1 nuclear factor, erythroid 2-like 1
NODAL nodal growth differentiation factor
OTX2 orthodenticle homeobox 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKNOX1 PBX/knotted 1 homeobox 1
PNN pinin, desmosome associated protein
PRICKLE1 prickle homolog 1 (Drosophila)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SRF serum response factor (c-fos serum response element-binding transcription factor)
T T, brachyury homolog (mouse)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TDGF1 teratocarcinoma-derived growth factor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLX2 T-cell leukemia homeobox 2
TPT1 tumor protein, translationally-controlled 1
TRIM33 tripartite motif containing 33
TSG101 tumor susceptibility 101
TXNRD1 thioredoxin reductase 1
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A