abnormal primitive node morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorly to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo (Mammalian Phenotype Ontology, MP_0004066)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004066
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53 gene mutations causing the abnormal primitive node morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AMN amnion associated transmembrane protein
APC adenomatous polyposis coli
ATMIN ATM interactor
B9D1 B9 protein domain 1
BICC1 BicC family RNA binding protein 1
BMP4 bone morphogenetic protein 4
C2CD3 C2 calcium-dependent domain containing 3
CCDC40 coiled-coil domain containing 40
CLUAP1 clusterin associated protein 1
DLL1 delta-like 1 (Drosophila)
DNAH11 dynein, axonemal, heavy chain 11
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
EOMES eomesodermin
FGF8 fibroblast growth factor 8 (androgen-induced)
FOXA2 forkhead box A2
FOXH1 forkhead box H1
FOXJ1 forkhead box J1
HTT huntingtin
IFT122 intraflagellar transport 122
IFT172 intraflagellar transport 172
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
INTU inturned planar cell polarity protein
INVS inversin
KIAA0586 KIAA0586
KIF3A kinesin family member 3A
KIF3B kinesin family member 3B
LEFTY2 left-right determination factor 2
LHX1 LIM homeobox 1
MBD4 methyl-CpG binding domain protein 4
MIXL1 Mix paired-like homeobox
MKS1 Meckel syndrome, type 1
NODAL nodal growth differentiation factor
NOTO notochord homeobox
NSD1 nuclear receptor binding SET domain protein 1
OTX2 orthodenticle homeobox 2
PIFO primary cilia formation
PKD2 polycystic kidney disease 2 (autosomal dominant)
POFUT2 protein O-fucosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SALL4 spalt-like transcription factor 4
SMAD2 SMAD family member 2
SUFU suppressor of fused homolog (Drosophila)
TBX6 T-box 6
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TMEM67 transmembrane protein 67
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
WDR35 WD repeat domain 35
WNT3 wingless-type MMTV integration site family, member 3
ZIC3 Zic family member 3