abnormal positive t cell selection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death (Mammalian Phenotype Ontology, MP_0004919)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004919
Similar Terms
Downloads & Tools

Genes

14 gene mutations causing the abnormal positive t cell selection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
HLA-DMA major histocompatibility complex, class II, DM alpha
ITK IL2-inducible T-cell kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
PRKCQ protein kinase C, theta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
THEMIS thymocyte selection associated
TOX thymocyte selection-associated high mobility group box
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa