abnormal plasmacytoid dendritic cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance (Mammalian Phenotype Ontology, MP_0008769)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008769
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7 gene mutations causing the abnormal plasmacytoid dendritic cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
IL21R interleukin 21 receptor
MB21D1 Mab-21 domain containing 1
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
TANK TRAF family member-associated NFKB activator
TLR9 toll-like receptor 9
TMEM173 transmembrane protein 173