abnormal plasmacytoid dendritic cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli (Mammalian Phenotype Ontology, MP_0008123)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008123
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Genes

11 gene mutations causing the abnormal plasmacytoid dendritic cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL3 B-cell CLL/lymphoma 3
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
GPR183 G protein-coupled receptor 183
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRF4 interferon regulatory factor 4
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PTPRC protein tyrosine phosphatase, receptor type, C
SPPL2A signal peptide peptidase like 2A
STAT2 signal transducer and activator of transcription 2, 113kDa