abnormal peyer's patch morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles (Mammalian Phenotype Ontology, MP_0000696)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000696
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Genes

76 gene mutations causing the abnormal peyer's patch morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGR2 anterior gradient 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
CA6 carbonic anhydrase VI
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CBFB core-binding factor, beta subunit
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD79B CD79b molecule, immunoglobulin-associated beta
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DOCK2 dedicator of cytokinesis 2
FAS Fas cell surface death receptor
FOXN1 forkhead box N1
FOXP3 forkhead box P3
GCSAM germinal center-associated, signaling and motility
GFRA1 GDNF family receptor alpha 1
ICOS inducible T-cell co-stimulator
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
IL7 interleukin 7
IL7R interleukin 7 receptor
IRAK3 interleukin-1 receptor-associated kinase 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB7 integrin, beta 7
JAK3 Janus kinase 3
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MIR155 microRNA 155
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-3 NK2 homeobox 3
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POLM polymerase (DNA directed), mu
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCARD PYD and CARD domain containing
RAG2 recombination activating gene 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
SASH3 SAM and SH3 domain containing 3
SHARPIN SHANK-associated RH domain interactor
SOCS1 suppressor of cytokine signaling 1
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
STK4 serine/threonine kinase 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIP1 TNFAIP3 interacting protein 1
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53