abnormal parietal yolk sac morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert's membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity (Mammalian Phenotype Ontology, MP_0011203)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011203
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Genes

123 gene mutations causing the abnormal parietal yolk sac morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABI1 abl-interactor 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARNT aryl hydrocarbon receptor nuclear translocator
ATAD3A ATPase family, AAA domain containing 3A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BMP5 bone morphogenetic protein 5
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CENPA centromere protein A
CHM choroideremia (Rab escort protein 1)
COL4A1 collagen, type IV, alpha 1
COPS2 COP9 signalosome subunit 2
CR1L complement component (3b/4b) receptor 1-like
CSNK2B casein kinase 2, beta polypeptide
CTCF CCCTC-binding factor (zinc finger protein)
CTDNEP1 CTD nuclear envelope phosphatase 1
CUL3 cullin 3
CUL7 cullin 7
CXXC1 CXXC finger protein 1
DAD1 defender against cell death 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNM1L dynamin 1-like
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EOMES eomesodermin
EPCAM epithelial cell adhesion molecule
ERF Ets2 repressor factor
ESRRB estrogen-related receptor beta
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVX1 even-skipped homeobox 1
FBXL5 F-box and leucine-rich repeat protein 5
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FKTN fukutin
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GMNN geminin, DNA replication inhibitor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
HAND1 heart and neural crest derivatives expressed 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HNF1B HNF1 homeobox B
HTT huntingtin
IL11RA interleukin 11 receptor, alpha
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
KDM6A lysine (K)-specific demethylase 6A
KLF5 Kruppel-like factor 5 (intestinal)
KRT8 keratin 8, type II
LAMA1 laminin, alpha 1
LAMB1 laminin, beta 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MDFI MyoD family inhibitor
MED1 mediator complex subunit 1
MESDC2 mesoderm development candidate 2
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NBN nibrin
NCOA6 nuclear receptor coactivator 6
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NF2 neurofibromin 2 (merlin)
NODAL nodal growth differentiation factor
PBRM1 polybromo 1
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLAC1 placenta-specific 1
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PMM2 phosphomannomutase 2
PNPLA6 patatin-like phospholipase domain containing 6
POFUT2 protein O-fucosyltransferase 2
POMT1 protein-O-mannosyltransferase 1
POMT2 protein-O-mannosyltransferase 2
POU2F1 POU class 2 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRDM1 PR domain containing 1, with ZNF domain
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RANGAP1 Ran GTPase activating protein 1
RECQL4 RecQ protein-like 4
RPTOR regulatory associated protein of MTOR, complex 1
RTEL1 regulator of telomere elongation helicase 1
RYBP RING1 and YY1 binding protein
SALL4 spalt-like transcription factor 4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC31A1 solute carrier family 31 (copper transporter), member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNX13 sorting nexin 13
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSB Sjogren syndrome antigen B (autoantigen La)
T T, brachyury homolog (mouse)
TEAD4 TEA domain family member 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
THBD thrombomodulin
TRRAP transformation/transcription domain-associated protein
TSG101 tumor susceptibility 101
TSIX TSIX transcript, XIST antisense RNA
TTPA tocopherol (alpha) transfer protein
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZNF830 zinc finger protein 830
ZPR1 ZPR1 zinc finger