abnormal pancreatic beta cell differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical production of or inability to produce the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas, and/or accumulation of pancreatic beta cell precursors (Mammalian Phenotype Ontology, MP_0009175)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009175
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Genes

8 gene mutations causing the abnormal pancreatic beta cell differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
GDF11 growth differentiation factor 11
ILDR2 immunoglobulin-like domain containing receptor 2
NKX2-2 NK2 homeobox 2
PCSK2 proprotein convertase subtilisin/kexin type 2
PDX1 pancreatic and duodenal homeobox 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
TLE3 transducin-like enhancer of split 3