abnormal pancreatic alpha cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas (Mammalian Phenotype Ontology, MP_0003563)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003563
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17 gene mutations causing the abnormal pancreatic alpha cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CHRM3 cholinergic receptor, muscarinic 3
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
FFAR1 free fatty acid receptor 1
GCGR glucagon receptor
GPER1 G protein-coupled estrogen receptor 1
IL6 interleukin 6
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LEPR leptin receptor
MIR375 microRNA 375
NKX2-2 NK2 homeobox 2
PCSK2 proprotein convertase subtilisin/kexin type 2
PDX1 pancreatic and duodenal homeobox 1
SNAP25 synaptosomal-associated protein, 25kDa
THRA thyroid hormone receptor, alpha
WFS1 Wolfram syndrome 1 (wolframin)