abnormal palate morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) (Mammalian Phenotype Ontology, MP_0003755)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003755
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Genes

207 gene mutations causing the abnormal palate morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAN aggrecan
ACVR2A activin A receptor, type IIA
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADGRA2 adhesion G protein-coupled receptor A2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APAF1 apoptotic peptidase activating factor 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPH aspartate beta-hydroxylase
ASXL1 additional sex combs like transcriptional regulator 1
B9D1 B9 protein domain 1
BARX1 BARX homeobox 1
BMP7 bone morphogenetic protein 7
BNC2 basonuclin 2
C5ORF42 chromosome 5 open reading frame 42
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CC2D2A coiled-coil and C2 domain containing 2A
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDON cell adhesion associated, oncogene regulated
CHD7 chromodomain helicase DNA binding protein 7
CHRD chordin
CHUK conserved helix-loop-helix ubiquitous kinase
CKAP5 cytoskeleton associated protein 5
COL11A1 collagen, type XI, alpha 1
COL2A1 collagen, type II, alpha 1
CRAMP1L Crm, cramped-like (Drosophila)
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRNP1 cysteine-serine-rich nuclear protein 1
CTGF connective tissue growth factor
CTNNBIP1 catenin, beta interacting protein 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLG1 discs, large homolog 1 (Drosophila)
DLX1 distal-less homeobox 1
DLX2 distal-less homeobox 2
DLX5 distal-less homeobox 5
DLX6 distal-less homeobox 6
DNM2 dynamin 2
DPH1 diphthamide biosynthesis 1
EDA ectodysplasin A
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFNA5 ephrin-A5
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EYA1 EYA transcriptional coactivator and phosphatase 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXO11 F-box protein 11
FGF10 fibroblast growth factor 10
FGF18 fibroblast growth factor 18
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FIGN fidgetin
FLNA filamin A, alpha
FOXC2 forkhead box C2
FOXE1 forkhead box E1
FOXF2 forkhead box F2
FRAS1 Fraser extracellular matrix complex subunit 1
FST follistatin
FUZ fuzzy planar cell polarity protein
FZD2 frizzled class receptor 2
GAB1 GRB2-associated binding protein 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GBX2 gastrulation brain homeobox 2
GDF11 growth differentiation factor 11
GLCE glucuronic acid epimerase
GLG1 golgi glycoprotein 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HAND2 heart and neural crest derivatives expressed 2
HHAT hedgehog acyltransferase
HIC1 hypermethylated in cancer 1
HOXA2 homeobox A2
HOXA3 homeobox A3
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPB11 heat shock protein family B (small), member 11
HSPG2 heparan sulfate proteoglycan 2
IFT140 intraflagellar transport 140
IFT172 intraflagellar transport 172
IFT27 intraflagellar transport 27
IFT88 intraflagellar transport 88
IMPAD1 inositol monophosphatase domain containing 1
INHBA inhibin, beta A
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF6 interferon regulatory factor 6
ITGAV integrin, alpha V
ITGB8 integrin, beta 8
JAG2 jagged 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDF1 keratinocyte differentiation factor 1
KIF7 kinesin family member 7
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LASP1 LIM and SH3 protein 1
LHX8 LIM homeobox 8
LMNA lamin A/C
LRP2 low density lipoprotein receptor-related protein 2
LRP6 low density lipoprotein receptor-related protein 6
LUZP1 leucine zipper protein 1
MEGF8 multiple EGF-like-domains 8
MEOX2 mesenchyme homeobox 2
MIDN midnolin
MKS1 Meckel syndrome, type 1
MN1 meningioma (disrupted in balanced translocation) 1
MNT MAX network transcriptional repressor
MSX1 msh homeobox 1
NABP2 nucleic acid binding protein 2
NCOA6 nuclear receptor coactivator 6
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
OCA2 oculocutaneous albinism II
OSR2 odd-skipped related transciption factor 2
OTX2 orthodenticle homeobox 2
PAK1IP1 PAK1 interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAX6 paired box 6
PAX9 paired box 9
PBX1 pre-B-cell leukemia homeobox 1
PC pyruvate carboxylase
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PHC1 polyhomeotic homolog 1 (Drosophila)
PITX1 paired-like homeodomain 1
PITX2 paired-like homeodomain 2
PKDCC protein kinase domain containing, cytoplasmic
PLXND1 plexin D1
PNN pinin, desmosome associated protein
PRDM16 PR domain containing 16
PRICKLE1 prickle homolog 1 (Drosophila)
PRRX1 paired related homeobox 1
PTCH1 patched 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAX retina and anterior neural fold homeobox
RECQL4 RecQ protein-like 4
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPL38 ribosomal protein L38
RSPO2 R-spondin 2
RUNX2 runt-related transcription factor 2
RYK receptor-like tyrosine kinase
RYR1 ryanodine receptor 1 (skeletal)
SALL3 spalt-like transcription factor 3
SATB2 SATB homeobox 2
SC5D sterol-C5-desaturase
SCHIP1 schwannomin interacting protein 1
SDCCAG8 serologically defined colon cancer antigen 8
SFN stratifin
SGPL1 sphingosine-1-phosphate lyase 1
SHOX2 short stature homeobox 2
SIM2 single-minded family bHLH transcription factor 2
SKOR2 SKI family transcriptional corepressor 2
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLMAP sarcolemma associated protein
SMAD7 SMAD family member 7
SMOC1 SPARC related modular calcium binding 1
SNAI2 snail family zinc finger 2
SOS1 son of sevenless homolog 1 (Drosophila)
SOSTDC1 sclerostin domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
SOX5 SRY (sex determining region Y)-box 5
SOX9 SRY (sex determining region Y)-box 9
SP8 Sp8 transcription factor
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SUFU suppressor of fused homolog (Drosophila)
SUMO1 small ubiquitin-like modifier 1
TAPT1 transmembrane anterior posterior transformation 1
TBC1D32 TBC1 domain family, member 32
TBX1 T-box 1
TBX10 T-box 10
TBX2 T-box 2
TBX22 T-box 22
TBX3 T-box 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TCTN2 tectonic family member 2
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM107 transmembrane protein 107
TP63 tumor protein p63
TRPS1 trichorhinophalangeal syndrome I
TSHZ1 teashirt zinc finger homeobox 1
TWIST1 twist family bHLH transcription factor 1
VAX1 ventral anterior homeobox 1
VEGFA vascular endothelial growth factor A
WDPCP WD repeat containing planar cell polarity effector
WDR19 WD repeat domain 19
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNT9B wingless-type MMTV integration site family, member 9B
ZEB1 zinc finger E-box binding homeobox 1
ZIC3 Zic family member 3