abnormal nk cell differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical production of or inability to produce mature lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells (Mammalian Phenotype Ontology, MP_0008053)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008053
Similar Terms
Downloads & Tools

Genes

10 gene mutations causing the abnormal nk cell differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
GFI1 growth factor independent 1 transcription repressor
IL11RA interleukin 11 receptor, alpha
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KLRK1 killer cell lectin-like receptor subfamily K, member 1
NFIL3 nuclear factor, interleukin 3 regulated
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
S1PR1 sphingosine-1-phosphate receptor 1
S1PR5 sphingosine-1-phosphate receptor 5
TBX21 T-box 21
TUSC2 tumor suppressor candidate 2