abnormal neutrophil physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal function of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes (Mammalian Phenotype Ontology, MP_0002463)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002463
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Genes

141 gene mutations causing the abnormal neutrophil physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA3 adenosine A3 receptor
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGAP15 Rho GTPase activating protein 15
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASXL1 additional sex combs like transcriptional regulator 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL2A1 BCL2-related protein A1
BCR breakpoint cluster region
BTK Bruton agammaglobulinemia tyrosine kinase
C3AR1 complement component 3a receptor 1
C5AR1 complement component 5a receptor 1
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD69 CD69 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCN3 chloride channel, voltage-sensitive 3
CLEC6A C-type lectin domain family 6, member A
CLEC7A C-type lectin domain family 7, member A
CMKLR1 chemerin chemokine-like receptor 1
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTSC cathepsin C
CTTN cortactin
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DOCK2 dedicator of cytokinesis 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FASTK Fas-activated serine/threonine kinase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FFAR2 free fatty acid receptor 2
FGG fibrinogen gamma chain
FLOT1 flotillin 1
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
G6PC3 glucose 6 phosphatase, catalytic, 3
GBP5 guanylate binding protein 5
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GSN gelsolin
HCK HCK proto-oncogene, Src family tyrosine kinase
HSPB1 heat shock 27kDa protein 1
HVCN1 hydrogen voltage gated channel 1
ICAM1 intercellular adhesion molecule 1
IL13 interleukin 13
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JDP2 Jun dimerization protein 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2E lysine (K)-specific methyltransferase 2E
LBP lipopolysaccharide binding protein
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS3 lectin, galactoside-binding, soluble, 3
LSP1 lymphocyte-specific protein 1
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LY96 lymphocyte antigen 96
MDK midkine (neurite growth-promoting factor 2)
MIR223 microRNA 223
MMP28 matrix metallopeptidase 28
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPP1 membrane protein, palmitoylated 1, 55kDa
MYD88 myeloid differentiation primary response 88
MYO1F myosin IF
NCF1 neutrophil cytosolic factor 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NCKAP1L NCK-associated protein 1-like
NLRP12 NLR family, pyrin domain containing 12
NLRX1 NLR family member X1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR1 natriuretic peptide receptor 1
PADI4 peptidyl arginine deiminase, type IV
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PGLYRP1 peptidoglycan recognition protein 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G10 phospholipase A2, group X
PLAC8 placenta-specific 8
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLD2 phospholipase D2
PRAM1 PML-RARA regulated adaptor molecule 1
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKCD protein kinase C, delta
PTN pleiotrophin
RAB27A RAB27A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1A RAP1A, member of RAS oncogene family
RASGRP4 RAS guanyl releasing protein 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S100A9 S100 calcium binding protein A9
SELE selectin E
SELK selenoprotein K
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFTPD surfactant protein D
SIGLEC9 sialic acid binding Ig-like lectin 9
SLAMF6 SLAM family member 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAD3 SMAD family member 3
SSTR4 somatostatin receptor 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STX11 syntaxin 11
SYK spleen tyrosine kinase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TPSAB1 tryptase alpha/beta 1
TRAF3IP2 TRAF3 interacting protein 2
TRPM2 transient receptor potential cation channel, subfamily M, member 2
WDR1 WD repeat domain 1