abnormal neutrophil cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A deviation from the normal range of neutrophil cell counts in the circulation. (Human Phenotype Ontology, HP_0011991)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012440
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Genes

183 gene mutations causing the abnormal neutrophil cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ANK1 ankyrin 1, erythrocytic
ARHGAP15 Rho GTPase activating protein 15
ARID4A AT rich interactive domain 4A (RBP1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASXL1 additional sex combs like transcriptional regulator 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAG3 BCL2-associated athanogene 3
BCL6B B-cell CLL/lymphoma 6, member B
BCR breakpoint cluster region
BHLHE41 basic helix-loop-helix family, member e41
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4A complement component 4A (Rodgers blood group)
CAMP cathelicidin antimicrobial peptide
CCL13 chemokine (C-C motif) ligand 13
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD19 CD19 molecule
CD300A CD300a molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERK ceramide kinase
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLCA1 chloride channel accessory 1
CLEC4E C-type lectin domain family 4, member E
CMKLR1 chemerin chemokine-like receptor 1
CNN2 calponin 2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DIAPH1 diaphanous-related formin 1
ESR2 estrogen receptor 2 (ER beta)
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASTK Fas-activated serine/threonine kinase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FES FES proto-oncogene, tyrosine kinase
FLT3LG fms-related tyrosine kinase 3 ligand
FOXN1 forkhead box N1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD9 frizzled class receptor 9
G6PC3 glucose 6 phosphatase, catalytic, 3
GALC galactosylceramidase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GFI1 growth factor independent 1 transcription repressor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNMT glycine N-methyltransferase
GSN gelsolin
GSX1 GS homeobox 1
HAX1 HCLS1 associated protein X-1
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFNB1 interferon, beta 1, fibroblast
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL1R1 interleukin 1 receptor, type I
IL1RL2 interleukin 1 receptor-like 2
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL36RN interleukin 36 receptor antagonist
IL5 interleukin 5
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK3 interleukin-1 receptor-associated kinase 3
IRF8 interferon regulatory factor 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK3 Janus kinase 3
KDM5A lysine (K)-specific demethylase 5A
KERA keratocan
KISS1R KISS1 receptor
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LEPR leptin receptor
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LUM lumican
LYN LYN proto-oncogene, Src family tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MFAP5 microfibrillar associated protein 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MINA MYC induced nuclear antigen
MIR223 microRNA 223
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NCKAP1L NCK-associated protein 1-like
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G10 phospholipase A2, group X
PLAC8 placenta-specific 8
PLSCR1 phospholipid scramblase 1
POMT1 protein-O-mannosyltransferase 1
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRF1 perforin 1 (pore forming protein)
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCH2 patched 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTRH2 peptidyl-tRNA hydrolase 2
RAB27A RAB27A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG1 recombination activating gene 1
RBP1 retinol binding protein 1, cellular
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SAMD9L sterile alpha motif domain containing 9-like
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SFTPD surfactant protein D
SGPL1 sphingosine-1-phosphate lyase 1
SH2B3 SH2B adaptor protein 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAD3 SMAD family member 3
SMAP1 small ArfGAP 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SPI1 Spi-1 proto-oncogene
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTA1 spectrin, alpha, erythrocytic 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX11 syntaxin 11
SYK spleen tyrosine kinase
TET1 tet methylcytosine dioxygenase 1
TET2 tet methylcytosine dioxygenase 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR5 toll-like receptor 5
TLX1 T-cell leukemia homeobox 1
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TSTA3 tissue specific transplantation antigen P35B
UNC13D unc-13 homolog D (C. elegans)
USP21 ubiquitin specific peptidase 21
USP25 ubiquitin specific peptidase 25
VTCN1 V-set domain containing T cell activation inhibitor 1
WAS Wiskott-Aldrich syndrome
WDR1 WD repeat domain 1
ZBTB46 zinc finger and BTB domain containing 46
ZDHHC13 zinc finger, DHHC-type containing 13
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM1 zinc finger protein, FOG family member 1