abnormal neuron differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses (Mammalian Phenotype Ontology, MP_0009937)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009937
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Genes

220 gene mutations causing the abnormal neuron differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
APAF1 apoptotic peptidase activating factor 1
ARHGAP32 Rho GTPase activating protein 32
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BDNF brain-derived neurotrophic factor
BHLHE22 basic helix-loop-helix family, member e22
BMPR1B bone morphogenetic protein receptor, type IB
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CCDC88A coiled-coil domain containing 88A
CCKAR cholecystokinin A receptor
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CFL1 cofilin 1 (non-muscle)
CHD7 chromodomain helicase DNA binding protein 7
CHN1 chimerin 1
CHN2 chimerin 2
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
CNTN1 contactin 1
CRTAC1 cartilage acidic protein 1
DAGLA diacylglycerol lipase, alpha
DCC DCC netrin 1 receptor
DCLK1 doublecortin-like kinase 1
DLG5 discs, large homolog 5 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DLX5 distal-less homeobox 5
DMRTA2 DMRT-like family A2
DSCAM Down syndrome cell adhesion molecule
EBF2 early B-cell factor 2
EFNA2 ephrin-A2
EFNB2 ephrin-B2
EFNB3 ephrin-B3
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EN1 engrailed homeobox 1
ENAH enabled homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA4 EPH receptor A4
EPHA8 EPH receptor A8
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FBXO45 F-box protein 45
FERD3L Fer3-like bHLH transcription factor
FEV FEV (ETS oncogene family)
FEZF1 FEZ family zinc finger 1
FEZF2 FEZ family zinc finger 2
FGF2 fibroblast growth factor 2 (basic)
FKBP8 FK506 binding protein 8, 38kDa
FKRP fukutin related protein
FMR1 fragile X mental retardation 1
FOXA2 forkhead box A2
FOXC1 forkhead box C1
FOXG1 forkhead box G1
FOXP2 forkhead box P2
FST follistatin
GAP43 growth associated protein 43
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GCM1 glial cells missing homolog 1 (Drosophila)
GCM2 glial cells missing homolog 2 (Drosophila)
GDF11 growth differentiation factor 11
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPHN gephyrin
GPM6A glycoprotein M6A
GPR37L1 G protein-coupled receptor 37 like 1
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GSX2 GS homeobox 2
HES1 hes family bHLH transcription factor 1
HOXA2 homeobox A2
HOXB1 homeobox B1
HOXB13 homeobox B13
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPG2 heparan sulfate proteoglycan 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
INSM1 insulinoma-associated 1
ISPD isoprenoid synthase domain containing
ITGB8 integrin, beta 8
JAG1 jagged 1
KIDINS220 kinase D-interacting substrate, 220kDa
KIF20B kinesin family member 20B
KIF26A kinesin family member 26A
KIF2A kinesin heavy chain member 2A
KIF7 kinesin family member 7
KLF7 Kruppel-like factor 7 (ubiquitous)
L1CAM L1 cell adhesion molecule
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
LHX5 LIM homeobox 5
LHX6 LIM homeobox 6
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMX1A LIM homeobox transcription factor 1, alpha
LMX1B LIM homeobox transcription factor 1, beta
LRRK2 leucine-rich repeat kinase 2
MAP1B microtubule-associated protein 1B
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPT microtubule-associated protein tau
MBD1 methyl-CpG binding domain protein 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCPH1 microcephalin 1
MEGF8 multiple EGF-like-domains 8
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
MET MET proto-oncogene, receptor tyrosine kinase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MNX1 motor neuron and pancreas homeobox 1
MUSK muscle, skeletal, receptor tyrosine kinase
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYD88 myeloid differentiation primary response 88
NCAM1 neural cell adhesion molecule 1
NDE1 nudE neurodevelopment protein 1
NEFH neurofilament, heavy polypeptide
NEFM neurofilament, medium polypeptide
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NES nestin
NEUROG2 neurogenin 2
NFIA nuclear factor I/A
NGEF neuronal guanine nucleotide exchange factor
NGFR nerve growth factor receptor
NKX2-8 NK2 homeobox 8
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOS1 nitric oxide synthase 1 (neuronal)
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR2E1 nuclear receptor subfamily 2, group E, member 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRG1 neuregulin 1
NRN1 neuritin 1
NRP1 neuropilin 1
NRP2 neuropilin 2
NTF4 neurotrophin 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUMB numb homolog (Drosophila)
OLIG3 oligodendrocyte transcription factor 3
OR8A1 olfactory receptor, family 8, subfamily A, member 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAX2 paired box 2
PAX6 paired box 6
PEX11B peroxisomal biogenesis factor 11 beta
PHGDH phosphoglycerate dehydrogenase
PHOX2A paired-like homeobox 2a
PHOX2B paired-like homeobox 2b
PITX2 paired-like homeodomain 2
PLXNA3 plexin A3
PLXNA4 plexin A4
PLXNB2 plexin B2
POLB polymerase (DNA directed), beta
POU3F2 POU class 3 homeobox 2
PRDM8 PR domain containing 8
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRNP prion protein
PROKR2 prokineticin receptor 2
PSEN1 presenilin 1
PTBP2 polypyrimidine tract binding protein 2
PTCH1 patched 1
PTF1A pancreas specific transcription factor, 1a
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRS protein tyrosine phosphatase, receptor type, S
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
REST RE1-silencing transcription factor
RET ret proto-oncogene
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RORA RAR-related orphan receptor A
RTN4 reticulon 4
RTN4R reticulon 4 receptor
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SFRP2 secreted frizzled-related protein 2
SH2D3C SH2 domain containing 3C
SKOR2 SKI family transcriptional corepressor 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMO smoothened, frizzled class receptor
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOX10 SRY (sex determining region Y)-box 10
SOX11 SRY (sex determining region Y)-box 11
SOX2 SRY (sex determining region Y)-box 2
SYN3 synapsin III
TBX1 T-box 1
TDO2 tryptophan 2,3-dioxygenase
TERT telomerase reverse transcriptase
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNIK TRAF2 and NCK interacting kinase
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TTL tubulin tyrosine ligase
TUBB3 tubulin, beta 3 class III
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UNC5D unc-5 homolog D (C. elegans)
VAMP7 vesicle-associated membrane protein 7
VAX1 ventral anterior homeobox 1
VAX2 ventral anterior homeobox 2
ZBTB18 zinc finger and BTB domain containing 18