abnormal neuron apoptosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description change in the timing or the number of neurons undergoing programmed cell death (Mammalian Phenotype Ontology, MP_0003202)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003202
Similar Terms
Downloads & Tools

Genes

167 gene mutations causing the abnormal neuron apoptosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
APC2 adenomatosis polyposis coli 2
ARHGAP1 Rho GTPase activating protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASTN1 astrotactin 1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAG6 BCL2-associated athanogene 6
BAX BCL2-associated X protein
BBS1 Bardet-Biedl syndrome 1
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAPRIN1 cell cycle associated protein 1
CASP12 caspase 12 (gene/pseudogene)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAST calpastatin
CCL13 chemokine (C-C motif) ligand 13
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CERS1 ceramide synthase 1
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CIT citron rho-interacting serine/threonine kinase
CNR1 cannabinoid receptor 1 (brain)
COQ9 coenzyme Q9
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERBB3 erb-b2 receptor tyrosine kinase 3
F2R coagulation factor II (thrombin) receptor
FAF1 Fas (TNFRSF6) associated factor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF8 fibroblast growth factor 8 (androgen-induced)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GFRA3 GDNF family receptor alpha 3
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX1 glutathione peroxidase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM2 glutamate receptor, metabotropic 2
GRN granulin
GSTM5 glutathione S-transferase mu 5
HAX1 HCLS1 associated protein X-1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BJ histone cluster 1, H2bj
HPCA hippocalcin
HRK harakiri, BCL2 interacting protein
HTRA2 HtrA serine peptidase 2
HYOU1 hypoxia up-regulated 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL34 interleukin 34
IL6 interleukin 6
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KIDINS220 kinase D-interacting substrate, 220kDa
KIF20B kinesin family member 20B
KRAS Kirsten rat sarcoma viral oncogene homolog
LBR lamin B receptor
LIG4 ligase IV, DNA, ATP-dependent
LYNX1 Ly6/neurotoxin 1
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAGED1 melanoma antigen family D1
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAOB monoamine oxidase B
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK10 mitogen-activated protein kinase 10
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPT microtubule-associated protein tau
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCPH1 microcephalin 1
MED1 mediator complex subunit 1
MKS1 Meckel syndrome, type 1
MMP9 matrix metallopeptidase 9
MUTYH mutY homolog
NGFR nerve growth factor receptor
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOVA1 neuro-oncological ventral antigen 1
NOX4 NADPH oxidase 4
NPAS4 neuronal PAS domain protein 4
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTF4 neurotrophin 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGG1 8-oxoguanine DNA glycosylase
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PANX1 pannexin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PARP1 poly (ADP-ribose) polymerase 1
PERP PERP, TP53 apoptosis effector
PEX11B peroxisomal biogenesis factor 11 beta
PINK1 PTEN induced putative kinase 1
PITX3 paired-like homeodomain 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLG plasminogen
POLB polymerase (DNA directed), beta
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRNP prion protein
PSEN1 presenilin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASD1 RAS, dexamethasone-induced 1
RB1 retinoblastoma 1
RBL2 retinoblastoma-like 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS7 ribosomal protein S7
S1PR1 sphingosine-1-phosphate receptor 1
SARM1 sterile alpha and TIR motif containing 1
SIX1 SIX homeobox 1
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
SRR serine racemase
STAT1 signal transducer and activator of transcription 1, 91kDa
STIM2 stromal interaction molecule 2
SUMF1 sulfatase modifying factor 1
SURF1 surfeit 1
SYNGAP1 synaptic Ras GTPase activating protein 1
TAL1 T-cell acute lymphocytic leukemia 1
TGFB3 transforming growth factor, beta 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TUBB2B tubulin, beta 2B class IIb
UBE2K ubiquitin-conjugating enzyme E2K
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC5A unc-5 homolog A (C. elegans)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VEGFA vascular endothelial growth factor A
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC13 zinc finger, DHHC-type containing 13
ZDHHC17 zinc finger, DHHC-type containing 17