abnormal neuroendocrine gland morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli (Mammalian Phenotype Ontology, MP_0000631)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000631
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Genes

106 gene mutations causing the abnormal neuroendocrine gland morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AES amino-terminal enhancer of split
ANXA1 annexin A1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASCL1 achaete-scute family bHLH transcription factor 1
ATCAY ataxia, cerebellar, Cayman type
ATG5 autophagy related 5
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BMP4 bone morphogenetic protein 4
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CGA glycoprotein hormones, alpha polypeptide
CHD7 chromodomain helicase DNA binding protein 7
CHGB chromogranin B
CRH corticotropin releasing hormone
CSHL1 chorionic somatomammotropin hormone-like 1
CYCS cytochrome c, somatic
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DDR2 discoidin domain receptor tyrosine kinase 2
DISP1 dispatched homolog 1 (Drosophila)
DMD dystrophin
DRD2 dopamine receptor D2
DUOX2 dual oxidase 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FBN1 fibrillin 1
FGF10 fibroblast growth factor 10
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR2 fibroblast growth factor receptor 2
FOXC1 forkhead box C1
FSHR follicle stimulating hormone receptor
FUZ fuzzy planar cell polarity protein
GAL galanin/GMAP prepropeptide
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GLI3 GLI family zinc finger 3
GSX1 GS homeobox 1
HES1 hes family bHLH transcription factor 1
HESX1 HESX homeobox 1
HHEX hematopoietically expressed homeobox
HMX2 H6 family homeobox 2
HMX3 H6 family homeobox 3
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
ISL1 ISL LIM homeobox 1
KL klotho
LATS1 large tumor suppressor kinase 1
LHX3 LIM homeobox 3
LHX4 LIM homeobox 4
MARK2 MAP/microtubule affinity-regulating kinase 2
MBD5 methyl-CpG binding domain protein 5
MEN1 multiple endocrine neoplasia I
MSX1 msh homeobox 1
NBEA neurobeachin
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEUROD1 neuronal differentiation 1
NKX2-1 NK2 homeobox 1
NOG noggin
NPC1 Niemann-Pick disease, type C1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A1 nuclear receptor subfamily 5, group A, member 1
OTP orthopedia homeobox
OTX2 orthodenticle homeobox 2
PAX8 paired box 8
PGAP1 post-GPI attachment to proteins 1
PITX1 paired-like homeodomain 1
PITX2 paired-like homeodomain 2
POU1F1 POU class 1 homeobox 1
POU3F2 POU class 3 homeobox 2
PRL prolactin
PROP1 PROP paired-like homeobox 1
PTPRS protein tyrosine phosphatase, receptor type, S
RB1 retinoblastoma 1
RET ret proto-oncogene
RFX4 regulatory factor X, 4 (influences HLA class II expression)
RPGRIP1L RPGRIP1-like
SCG5 secretogranin V
SERP1 stress-associated endoplasmic reticulum protein 1
SIM1 single-minded family bHLH transcription factor 1
SIX1 SIX homeobox 1
SIX6 SIX homeobox 6
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SOCS7 suppressor of cytokine signaling 7
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
STX1B syntaxin 1B
SYTL4 synaptotagmin-like 4
TBX19 T-box 19
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCOF1 Treacher Collins-Franceschetti syndrome 1
THRB thyroid hormone receptor, beta
TPST2 tyrosylprotein sulfotransferase 2
TPX2 TPX2, microtubule-associated
TRH thyrotropin-releasing hormone
TSHR thyroid stimulating hormone receptor
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WNT4 wingless-type MMTV integration site family, member 4
WWOX WW domain containing oxidoreductase