abnormal negative t cell selection Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process of elimination of immature T cells which react strongly with self-antigens (Mammalian Phenotype Ontology, MP_0004918)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004918
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Genes

13 gene mutations causing the abnormal negative t cell selection phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CD40LG CD40 ligand
FAS Fas cell surface death receptor
FYN FYN proto-oncogene, Src family tyrosine kinase
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
THEMIS thymocyte selection associated
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa