abnormal monocyte morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood (Mammalian Phenotype Ontology, MP_0002620)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002620
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Genes

117 gene mutations causing the abnormal monocyte morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AIRE autoimmune regulator
ARHGAP15 Rho GTPase activating protein 15
ARID4A AT rich interactive domain 4A (RBP1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASXL1 additional sex combs like transcriptional regulator 1
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
B9D1 B9 protein domain 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6B B-cell CLL/lymphoma 6, member B
CCL13 chemokine (C-C motif) ligand 13
CCL7 chemokine (C-C motif) ligand 7
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD7 chromodomain helicase DNA binding protein 7
CLEC4E C-type lectin domain family 4, member E
CNN2 calponin 2
CORO1A coronin, actin binding protein, 1A
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DIAPH1 diaphanous-related formin 1
DIDO1 death inducer-obliterator 1
DLL1 delta-like 1 (Drosophila)
ELMOD1 ELMO/CED-12 domain containing 1
EN1 engrailed homeobox 1
EPAS1 endothelial PAS domain protein 1
ESR2 estrogen receptor 2 (ER beta)
FES FES proto-oncogene, tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FOXP3 forkhead box P3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD9 frizzled class receptor 9
GFI1 growth factor independent 1 transcription repressor
GIMAP6 GTPase, IMAP family member 6
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNMT glycine N-methyltransferase
GPR68 G protein-coupled receptor 68
GPSM3 G-protein signaling modulator 3
HHEX hematopoietically expressed homeobox
HRG histidine-rich glycoprotein
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF8 interferon regulatory factor 8
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KISS1R KISS1 receptor
KMT2A lysine (K)-specific methyltransferase 2A
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
MIR122 microRNA 122
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPZ myelin protein zero
MRPL54 mitochondrial ribosomal protein L54
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NF1 neurofibromin 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDLIM7 PDZ and LIM domain 7 (enigma)
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS50 protease, serine, 50
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG2 recombination activating gene 2
RUNX1 runt-related transcription factor 1
SELL selectin L
SENP1 SUMO1/sentrin specific peptidase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETD5 SET domain containing 5
SGPL1 sphingosine-1-phosphate lyase 1
SH2B3 SH2B adaptor protein 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD3 SMAD family member 3
SORBS1 sorbin and SH3 domain containing 1
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
TBK1 TANK-binding kinase 1
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TMUB1 transmembrane and ubiquitin-like domain containing 1
TNIP1 TNFAIP3 interacting protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN33 tetraspanin 33
TWSG1 twisted gastrulation BMP signaling modulator 1
UNC13D unc-13 homolog D (C. elegans)
VCAM1 vascular cell adhesion molecule 1
WAS Wiskott-Aldrich syndrome
ZBTB46 zinc finger and BTB domain containing 46
ZFP36 ZFP36 ring finger protein
ZFPM1 zinc finger protein, FOG family member 1