abnormal microglial cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques (Mammalian Phenotype Ontology, MP_0003691)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003691
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Genes

34 gene mutations causing the abnormal microglial cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ATM ATM serine/threonine kinase
CCL13 chemokine (C-C motif) ligand 13
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CLCN2 chloride channel, voltage-sensitive 2
CLCN3 chloride channel, voltage-sensitive 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DOCK3 dedicator of cytokinesis 3
EGR1 early growth response 1
GRN granulin
IDUA iduronidase, alpha-L-
IFNB1 interferon, beta 1, fibroblast
IL6 interleukin 6
LEP leptin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2C1 mannosidase, alpha, class 2C, member 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NPC1 Niemann-Pick disease, type C1
PARP1 poly (ADP-ribose) polymerase 1
PLAT plasminogen activator, tissue
PLG plasminogen
PPT1 palmitoyl-protein thioesterase 1
PSAP prosaposin
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SARM1 sterile alpha and TIR motif containing 1
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)