abnormal meiosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the process of nuclear division that results in gametes with one half the normal number of the original cell (Mammalian Phenotype Ontology, MP_0001930)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001930
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Genes

154 gene mutations causing the abnormal meiosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGO4 argonaute RISC catalytic component 4
AKAP1 A kinase (PRKA) anchor protein 1
AKAP9 A kinase (PRKA) anchor protein 9
AR androgen receptor
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1
ATM ATM serine/threonine kinase
BAX BCL2-associated X protein
BRDT bromodomain, testis-specific
BRWD1 bromodomain and WD repeat domain containing 1
BSG basigin (Ok blood group)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCDC79 coiled-coil domain containing 79
CCNA1 cyclin A1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK2 cyclin-dependent kinase 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CGA glycoprotein hormones, alpha polypeptide
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CKS2 CDC28 protein kinase regulatory subunit 2
CNBD2 cyclic nucleotide binding domain containing 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREM cAMP responsive element modulator
CTCFL CCCTC-binding factor (zinc finger protein)-like
CUL4A cullin 4A
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DICER1 dicer 1, ribonuclease type III
DMC1 DNA meiotic recombinase 1
DMRT1 doublesex and mab-3 related transcription factor 1
DMRTC2 DMRT-like family C2
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
EGR4 early growth response 4
EHD1 EH-domain containing 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EWSR1 EWS RNA-binding protein 1
EXO1 exonuclease 1
FANCA Fanconi anemia, complementation group A
FANCD2 Fanconi anemia, complementation group D2
FKBP6 FK506 binding protein 6, 36kDa
FMN2 formin 2
FUS FUS RNA binding protein
GAL3ST1 galactose-3-O-sulfotransferase 1
GJA4 gap junction protein, alpha 4, 37kDa
GNPAT glyceronephosphate O-acyltransferase
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPR3 G protein-coupled receptor 3
GTSF1 gametocyte specific factor 1
H2AFX H2A histone family, member X
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HORMAD1 HORMA domain containing 1
HORMAD2 HORMA domain containing 2
HSF1 heat shock transcription factor 1
HSF2 heat shock transcription factor 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
ING2 inhibitor of growth family, member 2
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIAA0430 KIAA0430
KIF18A kinesin family member 18A
KISS1R KISS1 receptor
KL klotho
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LMNA lamin A/C
LOC101929327
M1AP meiosis 1 associated protein
MAEL maelstrom spermatogenic transposon silencer
MAP2 microtubule-associated protein 2
MAP7 microtubule-associated protein 7
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MEI1 meiosis inhibitor 1
MEI4 meiosis-specific 4 homolog (S. cerevisiae)
MEIOB meiosis specific with OB domains
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae)
MORC1 MORC family CW-type zinc finger 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MOV10L1 Mov10 RISC complex RNA helicase like 1
MSH4 mutS homolog 4
MSH5 mutS homolog 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDC1 NDC1 transmembrane nucleoporin
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPC natriuretic peptide C
NPR2 natriuretic peptide receptor 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
NXF2 nuclear RNA export factor 2
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PDE3A phosphodiesterase 3A, cGMP-inhibited
PIWIL1 piwi-like RNA-mediated gene silencing 1
PIWIL2 piwi-like RNA-mediated gene silencing 2
PIWIL4 piwi-like RNA-mediated gene silencing 4
PLD6 phospholipase D family, member 6
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRDM9 PR domain containing 9
PROKR2 prokineticin receptor 2
PSMC3IP PSMC3 interacting protein
PTH2 parathyroid hormone 2
RAD21 RAD21 homolog (S. pombe)
RAD21L1 RAD21-like 1 (S. pombe)
RAD51C RAD51 paralog C
RANBP9 RAN binding protein 9
REC8 REC8 meiotic recombination protein
RNF212 ring finger protein 212
RSPO1 R-spondin 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SGOL2 shugoshin-like 2 (S. pombe)
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SMC1B structural maintenance of chromosomes 1B
SPATA22 spermatogenesis associated 22
SPIN1 spindlin 1
SPO11 SPO11 meiotic protein covalently bound to DSB
STRA8 stimulated by retinoic acid 8
STX2 syntaxin 2
SUN1 Sad1 and UNC84 domain containing 1
SYCE1 synaptonemal complex central element protein 1
SYCE2 synaptonemal complex central element protein 2
SYCE3 synaptonemal complex central element protein 3
SYCP1 synaptonemal complex protein 1
SYCP2 synaptonemal complex protein 2
SYCP3 synaptonemal complex protein 3
TDRD5 tudor domain containing 5
TDRD9 tudor domain containing 9
TDRKH tudor and KH domain containing
TERC telomerase RNA component
TET1 tet methylcytosine dioxygenase 1
TEX11 testis expressed 11
TEX12 testis expressed 12
TEX14 testis expressed 14
TEX15 testis expressed 15
TOP3B topoisomerase (DNA) III beta
TP73 tumor protein p73
TRIP13 thyroid hormone receptor interactor 13
TSC22D3 TSC22 domain family, member 3
TSN translin
UBB ubiquitin B
UBE2B ubiquitin-conjugating enzyme E2B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VRK1 vaccinia related kinase 1
ZC3HC1 zinc finger, C3HC-type containing 1