abnormal megakaryocyte differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical production of or inability to produce of a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm (Mammalian Phenotype Ontology, MP_0000229)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000229
Similar Terms
Downloads & Tools

Genes

15 gene mutations causing the abnormal megakaryocyte differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C6ORF25 chromosome 6 open reading frame 25
GATA1 GATA binding protein 1 (globin transcription factor 1)
GFI1B growth factor independent 1B transcription repressor
GP1BA glycoprotein Ib (platelet), alpha polypeptide
JAK2 Janus kinase 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MMP9 matrix metallopeptidase 9
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RANBP10 RAN binding protein 10
RASA3 RAS p21 protein activator 3
ZFPM1 zinc finger protein, FOG family member 1