abnormal mast cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an anomaly in the number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation (Mammalian Phenotype Ontology, MP_0020203)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020203
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Genes

25 gene mutations causing the abnormal mast cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGR2 anterior gradient 2
C3 complement component 3
CCR1 chemokine (C-C motif) receptor 1
CD44 CD44 molecule (Indian blood group)
CPA3 carboxypeptidase A3 (mast cell)
DSG3 desmoglein 3
FBN1 fibrillin 1
GAB2 GRB2-associated binding protein 2
HDC histidine decarboxylase
ITGB7 integrin, beta 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MITF microphthalmia-associated transcription factor
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SHARPIN SHANK-associated RH domain interactor
SPRED1 sprouty-related, EVH1 domain containing 1
SRGN serglycin
STAT5A signal transducer and activator of transcription 5A
T T, brachyury homolog (mouse)