abnormal macrophage cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an anomaly in the number of macrophages (Mammalian Phenotype Ontology, MP_0020202)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0020202
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Genes

170 gene mutations causing the abnormal macrophage cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRE1 adhesion G protein-coupled receptor E1
ADGRF5 adhesion G protein-coupled receptor F5
AGER advanced glycosylation end product-specific receptor
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ANKRD11 ankyrin repeat domain 11
APC adenomatous polyposis coli
ARHGAP15 Rho GTPase activating protein 15
ASL argininosuccinate lyase
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCL3 B-cell CLL/lymphoma 3
BGLAP bone gamma-carboxyglutamate (gla) protein
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4A complement component 4A (Rodgers blood group)
C5AR1 complement component 5a receptor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARTPT CART prepropeptide
CCBE1 collagen and calcium binding EGF domains 1
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD200 CD200 molecule
CD47 CD47 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLCN7 chloride channel, voltage-sensitive 7
CLDN18 claudin 18
CLEC2D C-type lectin domain family 2, member D
CNN2 calponin 2
CNOT3 CCR4-NOT transcription complex, subunit 3
COL10A1 collagen, type X, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTSK cathepsin K
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DOK3 docking protein 3
EBF1 early B-cell factor 1
EGR1 early growth response 1
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBLIM1 filamin binding LIM protein 1
FGFR3 fibroblast growth factor receptor 3
FLT3LG fms-related tyrosine kinase 3 ligand
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GAB2 GRB2-associated binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GGT1 gamma-glutamyltransferase 1
GJD4 gap junction protein, delta 4, 40.1kDa
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR55 G protein-coupled receptor 55
GPR68 G protein-coupled receptor 68
HCST hematopoietic cell signal transducer
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HR hair growth associated
HSPG2 heparan sulfate proteoglycan 2
IAPP islet amyloid polypeptide
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFNB1 interferon, beta 1, fibroblast
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13 interleukin 13
IL18 interleukin 18
IL1RL2 interleukin 1 receptor-like 2
IL2RG interleukin 2 receptor, gamma
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK3 interleukin-1 receptor-associated kinase 3
IRF8 interferon regulatory factor 8
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KL klotho
KLF15 Kruppel-like factor 15
KMT2E lysine (K)-specific methyltransferase 2E
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LITAF lipopolysaccharide-induced TNF factor
LRP5 low density lipoprotein receptor-related protein 5
LRRK1 leucine-rich repeat kinase 1
LSP1 lymphocyte-specific protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
LYST lysosomal trafficking regulator
MAEA macrophage erythroblast attacher
MC4R melanocortin 4 receptor
MDK midkine (neurite growth-promoting factor 2)
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
MINA MYC induced nuclear antigen
MIR122 microRNA 122
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPZ myelin protein zero
MSI2 musashi RNA-binding protein 2
MSX2 msh homeobox 2
NCOR2 nuclear receptor corepressor 2
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
NPC1 Niemann-Pick disease, type C1
NPY2R neuropeptide Y receptor Y2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POSTN periostin, osteoblast specific factor
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROX1 prospero homeobox 1
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
SCTR secretin receptor
SFTPD surfactant protein D
SGPL1 sphingosine-1-phosphate lyase 1
SH3BP2 SH3-domain binding protein 2
SHCBP1 SHC SH2-domain binding protein 1
SIRT7 sirtuin 7
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STEAP4 STEAP family member 4
SUCO SUN domain containing ossification factor
SUMF1 sulfatase modifying factor 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TMEM64 transmembrane protein 64
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOB2 transducer of ERBB2, 2
TRIB1 tribbles pseudokinase 1
TRPV5 transient receptor potential cation channel, subfamily V, member 5
USP21 ubiquitin specific peptidase 21
VCP valosin containing protein
WDR1 WD repeat domain 1