abnormal lymph node morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue, and is the site where acquired immune responses are launched (Mammalian Phenotype Ontology, MP_0002339)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002339
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Genes

237 gene mutations causing the abnormal lymph node morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALOX15 arachidonate 15-lipoxygenase
ANGPTL4 angiopoietin-like 4
ANK1 ankyrin 1, erythrocytic
ATM ATM serine/threonine kinase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CARD11 caspase recruitment domain family, member 11
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL25 chemokine (C-C motif) ligand 25
CCR7 chemokine (C-C motif) receptor 7
CCR9 chemokine (C-C motif) receptor 9
CCRL2 chemokine (C-C motif) receptor-like 2
CD200 CD200 molecule
CD247 CD247 molecule
CD37 CD37 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHD2 chromodomain helicase DNA binding protein 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CIITA class II, major histocompatibility complex, transactivator
CISH cytokine inducible SH2-containing protein
CLEC10A C-type lectin domain family 10, member A
COL10A1 collagen, type X, alpha 1
CORO1A coronin, actin binding protein, 1A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSV cathepsin V
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DIAPH1 diaphanous-related formin 1
DOCK2 dedicator of cytokinesis 2
DSG4 desmoglein 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB2 ephrin-B2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F2R coagulation factor II (thrombin) receptor
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FOXC2 forkhead box C2
FOXN1 forkhead box N1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FZD9 frizzled class receptor 9
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPR132 G protein-coupled receptor 132
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HPGDS hematopoietic prostaglandin D synthase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HR hair growth associated
ICOS inducible T-cell co-stimulator
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10RB interleukin 10 receptor, beta
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL1RL2 interleukin 1 receptor-like 2
IL2 interleukin 2
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL34 interleukin 34
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
IRF8 interferon regulatory factor 8
ITGA6 integrin, alpha 6
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK3 Janus kinase 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KLHL6 kelch-like family member 6
KMT2E lysine (K)-specific methyltransferase 2E
LAT linker for activation of T cells
LBR lamin B receptor
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIPA lipase A, lysosomal acid, cholesterol esterase
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARK2 MAP/microtubule affinity-regulating kinase 2
MCM4 minichromosome maintenance complex component 4
MEFV Mediterranean fever
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MSMB microseminoprotein, beta-
MUC2 mucin 2, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCKAP1L NCK-associated protein 1-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NKX2-3 NK2 homeobox 3
NLK nemo-like kinase
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
PBX1 pre-B-cell leukemia homeobox 1
PDCD1LG2 programmed cell death 1 ligand 2
PELI1 pellino E3 ubiquitin protein ligase 1
PI16 peptidase inhibitor 16
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP prolactin-induced protein
PKP3 plakophilin 3
PLCD1 phospholipase C, delta 1
PLG plasminogen
POLB polymerase (DNA directed), beta
POU2AF1 POU class 2 associating factor 1
PRF1 perforin 1 (pore forming protein)
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS3 regulator of G-protein signaling 3
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
S1PR3 sphingosine-1-phosphate receptor 3
SATB1 SATB homeobox 1
SELL selectin L
SGPL1 sphingosine-1-phosphate lyase 1
SH2B3 SH2B adaptor protein 3
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD3 SMAD family member 3
SNORD50A small nucleolar RNA, C/D box 50A
SNORD50B small nucleolar RNA, C/D box 50B
SOCS1 suppressor of cytokine signaling 1
SPHK1 sphingosine kinase 1
SPTA1 spectrin, alpha, erythrocytic 1
TANK TRAF family member-associated NFKB activator
TBXA2R thromboxane A2 receptor
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNIP1 TNFAIP3 interacting protein 1
TNS2 tensin 2
TOM1L2 target of myb1-like 2 (chicken)
TOP3B topoisomerase (DNA) III beta
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TP63 tumor protein p63
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAT1 T cell receptor associated transmembrane adaptor 1
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TXNIP thioredoxin interacting protein
UNC13D unc-13 homolog D (C. elegans)
UNG uracil-DNA glycosylase
VAV1 vav 1 guanine nucleotide exchange factor
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB46 zinc finger and BTB domain containing 46
ZC3H12A zinc finger CCCH-type containing 12A
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein