abnormal lymph node germinal center morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells (Mammalian Phenotype Ontology, MP_0008522)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008522
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Genes

20 gene mutations causing the abnormal lymph node germinal center morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTK Bruton agammaglobulinemia tyrosine kinase
CCR7 chemokine (C-C motif) receptor 7
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CXCL13 chemokine (C-X-C motif) ligand 13
IRF4 interferon regulatory factor 4
KLHL6 kelch-like family member 6
LAT linker for activation of T cells
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
RC3H1 ring finger and CCCH-type domains 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
TNF tumor necrosis factor
TRAF2 TNF receptor-associated factor 2
UNC13D unc-13 homolog D (C. elegans)