abnormal leukocyte migration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description altered ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV (Mammalian Phenotype Ontology, MP_0003156)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003156
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Genes

123 gene mutations causing the abnormal leukocyte migration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ADORA2B adenosine A2b receptor
ANGPTL2 angiopoietin-like 2
AOC3 amine oxidase, copper containing 3
ARNTL aryl hydrocarbon receptor nuclear translocator-like
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CAPN1 calpain 1, (mu/I) large subunit
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CMKLR1 chemerin chemokine-like receptor 1
CNN2 calponin 2
CORO1A coronin, actin binding protein, 1A
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSC cathepsin C
CTTN cortactin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR5 chemokine (C-X-C motif) receptor 5
CYTIP cytohesin 1 interacting protein
DIAPH1 diaphanous-related formin 1
DOCK2 dedicator of cytokinesis 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
ESAM endothelial cell adhesion molecule
EVL Enah/Vasp-like
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLT1 fms-related tyrosine kinase 1
FPR2 formyl peptide receptor 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FYB FYN binding protein
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLB1 galactosidase, beta 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR132 G protein-coupled receptor 132
GPR34 G protein-coupled receptor 34
GPSM3 G-protein signaling modulator 3
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL4R interleukin 4 receptor
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
JMJD6 jumonji domain containing 6
LGALS3 lectin, galactoside-binding, soluble, 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LITAF lipopolysaccharide-induced TNF factor
LSP1 lymphocyte-specific protein 1
LTB4R leukotriene B4 receptor
MDK midkine (neurite growth-promoting factor 2)
MMP28 matrix metallopeptidase 28
MMP7 matrix metallopeptidase 7
MPZ myelin protein zero
MYH9 myosin, heavy chain 9, non-muscle
MYO9B myosin IXB
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NINJ1 ninjurin 1
NKX2-3 NK2 homeobox 3
NLRP12 NLR family, pyrin domain containing 12
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
PARP1 poly (ADP-ribose) polymerase 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PILRA paired immunoglobin-like type 2 receptor alpha
PLAU plasminogen activator, urokinase
PLEC plectin
PON2 paraoxonase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTGES prostaglandin E synthase
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAP1A RAP1A, member of RAS oncogene family
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
REL v-rel avian reticuloendotheliosis viral oncogene homolog
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
S100A4 S100 calcium binding protein A4
S100A9 S100 calcium binding protein A9
S1PR1 sphingosine-1-phosphate receptor 1
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SGPL1 sphingosine-1-phosphate lyase 1
SH2D3C SH2 domain containing 3C
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPP1 secreted phosphoprotein 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX21 T-box 21
THBD thrombomodulin
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TRAF3IP2 TRAF3 interacting protein 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin